Bioactive Penicipyrrodiether A, an Adduct of GKK1032 Analogue and Phenol A Derivative, from a Marine-Sourced Fungus Penicillium sp. ZZ380

Penicipyrrodiether A, an adduct of GKK1032 analogue and phenol A derivative, was isolated from a culture of marine-associated fungus Penicillium sp. ZZ380 and represents the first example of this type of fungal metabolite. Its structure was elucidated by extensive spectroscopic analyses, including 1...

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Bibliographic Details
Published in:Journal of organic chemistry 2018-11, Vol.83 (21), p.13395-13401
Main Authors: Song, Tengfei, Chen, Mengxuan, Ge, Zhi-Wei, Chai, Weiyun, Li, Xing-Cong, Zhang, Zhizhen, Lian, Xiao-Yuan
Format: Article
Language:English
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Summary:Penicipyrrodiether A, an adduct of GKK1032 analogue and phenol A derivative, was isolated from a culture of marine-associated fungus Penicillium sp. ZZ380 and represents the first example of this type of fungal metabolite. Its structure was elucidated by extensive spectroscopic analyses, including 1D- and 2D-NMR, HRESIMS, MS/MS, and electronic circular dichroism calculation as well as single-crystal X-ray diffraction. Penicipyrrodiether A showed antibacterial activity in inhibiting the growth of methicillin-resistant Staphylococcus aureus with a MIC value of 5.0 μg/mL. Its plausible pathway for biosynthesis has been proposed.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b02172