Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease

Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation...

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Bibliographic Details
Published in:Movement disorders 2004-11, Vol.19 (11), p.1328-1333
Main Authors: Timmermann, Lars, Wojtecki, Lars, Gross, Joachim, Lehrke, Ralph, Voges, Jürgen, Maarouf, Mohammed, Treuer, Harald, Sturm, Volker, Schnitzler, Alfons
Format: Article
Language:English
Subjects:
Aged
akinesia
Antiparkinson Agents - adverse effects
Antiparkinson Agents - therapeutic use
Biological and medical sciences
deep brain stimulation
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dominance, Cerebral - physiology
Drug Therapy, Combination
Electric Conductivity
Electric Stimulation Therapy
Electrodes, Implanted
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Levodopa - adverse effects
Levodopa - therapeutic use
Male
Medical sciences
Middle Aged
Motor Activity - physiology
Nerve Net - physiopathology
Nervous system (semeiology, syndromes)
Neurologic Examination
Neurology
oscillations
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Stereotaxic Techniques
Subthalamic Nucleus - physiopathology
Surgery, Computer-Assisted
synchronization
Treatment Failure
tremor
Tremor - physiopathology
Tremor - therapy
UPDRS
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Description
Summary:Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (≥130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD. © 2004 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.20198