Clinical Features and Genotypes of Patients with Hemoglobin H Disease in Taiwan

The genetic background of patients with hemoglobin (Hb) H disease in Taiwan has been investigated; however, the clinical features and treatment outcomes were not reported. To analyze the clinical features and genotypes of patients with HbH who reside in Taiwan. We conducted a retrospective analysis...

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Bibliographic Details
Published in:Laboratory medicine 2019-04, Vol.50 (2), p.168-173
Main Authors: Lin, Pei-Chin, Chang, Tai-Tsung, Liao, Yu-Mei, Tsai, Shih-Pien, Chen, Yen-Chu, Hsu, Wan-Yi, Su, Hsiu-Lan, Zeng, Yu-Sheng, Tseng, Yu-Hsin, Chiou, Shyh-Shin
Format: Article
Language:English
Subjects:
Adolescent
Adult
alpha-Thalassemia - complications
alpha-Thalassemia - epidemiology
alpha-Thalassemia - genetics
alpha-Thalassemia - therapy
Body weight
Body Weight - physiology
Care and treatment
Chelation therapy
Child
Child, Preschool
Development and progression
Diseases
Female
Genetic aspects
Genotypes
Glycosylated hemoglobin
Health aspects
Hemoglobin
Hemoglobinopathies
Hemoglobins
Hemoglobins - analysis
Humans
Male
Medical research
Medical schools
Middle Aged
Retrospective Studies
Splenectomy
Surgery
Taiwan - epidemiology
Thalassemia
Young Adult
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Summary:The genetic background of patients with hemoglobin (Hb) H disease in Taiwan has been investigated; however, the clinical features and treatment outcomes were not reported. To analyze the clinical features and genotypes of patients with HbH who reside in Taiwan. We conducted a retrospective analysis of the clinical and molecular characteristics of 38 patients with HbH disease who were undergoing treatment at Kaohsiung Medical University Hospital, Taiwan. Initial Hb levels were lower and the numbers of patients requiring iron-chelation therapy were higher in the nondeletional HbH group than in the deletional HbH group (P
ISSN:0007-5027
1943-7730
DOI:10.1093/labmed/lmy043