Relationship between variants of 17 newly loci and Parkinson's disease in a Chinese population

• Published in: Neurobiology of aging 2019-01, Vol.73, p.230.e1-230.e4
• Main Authors: Chen, Xiang, Xiao, Yousheng, Guo, Wenyuan, Zhou, Miaomiao, Huang, Shuxuan, Mo, Mingshu, Li, Zhe, Li, Guihua, Liu, Hanqun, Peng, Guoyou, Wu, Zhuohua, Wu, Yijuan, Yang, Chaohao, Pei, Zhong, Chen, Chaojun, Xu, Pingyi
• Format: Article
• Language: English
• Subjects: Aged; Asian Continental Ancestry Group - genetics; Association; Case-Control Studies; Female; Gene variants; Genetic Association Studies; Genotype; Humans; Male; Middle Aged; Parkinson Disease - genetics; Parkinson's disease; Polymorphism, Single Nucleotide - genetics; Risk
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2018.08.017

Genetic factors play significant roles in the causes of Parkinson's disease (PD). Recently, a meta-analysis of genome-wide association study (GWAS) has identified 17 loci associated with PD. The objective of our study was to investigate the association of 17 single-nucleotide polymorphisms with the risk of PD in Chinese population. We performed a case-control association study, and 1189 subjects comprising 652 PD patients and 537 controls were genotyped by using a Mass ARRAY System or a TaqMan assay. We found that rs601999 (OR (95% CI) = 3.378 (2.273–5.051), p < 0.001), rs11343 (OR (95% CI) = 0.426 (0.210–0.862), p = 0.018), rs353116 (OR (95% CI) = 0.738 (0.577–0.943), p = 0.015), and rs2280104 (OR (95% CI) = 1.371 (1.078–1.743), p = 0.010) were significantly associated with PD in Chinese population. However, no significant association was found in the remaining 13 single-nucleotide polymorphisms between both groups.