Metal/metalloid levels in urine and seminal plasma in relation to computer-aided sperm analysis motion parameters

Exposure to high levels of metals/metalloids may impair semen quality. Computer-aided sperm analysis (CASA) can be used for kinematic analysis of spermatozoa, which provides additional insights into sperm motion characteristics. To explore the associations of urinary and seminal plasma metal/metallo...

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Bibliographic Details
Published in:Chemosphere (Oxford) 2019-01, Vol.214, p.791-800
Main Authors: Wan, Zhen-Zhen, Chen, Heng-Gui, Lu, Wen-Qing, Wang, Yi-Xin, Pan, An
Format: Article
Language:English
Subjects:
CASA motion parameters
Dimenhydrinate - chemistry
epidemiology
Humans
Male
Metalloids - urine
metals
Semen - chemistry
Semen Analysis - methods
seminal plasma
Spermatozoa - physiology
urine
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Summary:Exposure to high levels of metals/metalloids may impair semen quality. Computer-aided sperm analysis (CASA) can be used for kinematic analysis of spermatozoa, which provides additional insights into sperm motion characteristics. To explore the associations of urinary and seminal plasma metal/metalloid concentrations with CASA motion parameters and assess the degree of correspondence between the two sample types. Eighteen metals/metalloids in seminal plasma and repeated urine samples were determined among 746 men recruited from a reproductive center. We assessed their associations with 6 CASA motion parameters [i.e., straight-line velocity (VSL), curvilinear velocity (VCL), average path velocity (VAP), linearity (LIN), straightness (STR) and amplitude head displacement (ALH)] using multivariable linear regression models. We found significantly inverse dose-dependent relationships between seminal plasma arsenic (As) and VSL, VCL and VAP, between seminal plasma selenium (Se) and VSL and VAP, between seminal plasma zinc (Zn) and STR and LIN, and between seminal plasma manganese (Mn) and LIN in single-metal models [all false discovery rate (FDR) adjusted P for trend 
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2018.10.001