Poly(d,l-lactic-co-glycolic acid) (PLGA) hollow fiber with segmental switchability of its chains sensitive to NIR light for synergistic cancer therapy

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-01, Vol.173, p.258-265
• Main Authors: Choi, Ji Hyun, Seo, Hojun, Park, Ju Hyang, Son, Jin Ho, Kim, Da In, Kim, Jongbok, Moon, Geon Dae, Hyun, Dong Choon
• Format: Article
• Language: English
• Subjects: Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacology; Anticancer; Cell Death - drug effects; Cell Line, Tumor; Cetrimonium - chemistry; Delayed-Action Preparations; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug Compounding - methods; Drug Delivery Systems - methods; Drug Liberation; Electrochemical Techniques; Electrospinning; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelial Cells - radiation effects; Female; Gold - chemistry; Humans; Hyperthermia, Induced - methods; Infrared Rays; Kinetics; Low-Level Light Therapy - methods; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Nanotubes - chemistry; Nanotubes - ultrastructure; NIR light-triggered drug release; Photothermal therapy; PLGA fibers; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2018.09.081

[Display omitted] •AuNR-incorporated PLGA hollow fibers have been fabricated.•The fibers release pre-loaded anticancer drug in response to NIR light.•The on–off switching of NIR light allows a repeated dosing of the drug.•The on-demand release has a synergistic anticancer activity with PTT. This work introduces a new fibrous system for synergistic cancer therapy. The system consists of poly(d,l-lactic-co-glycolic acid) (PLGA) fibers with a core encapsulating an anticancer drug and a shell entrapping gold nanorods (AuNRs) as a photothermal agent. On exposure to NIR light, the photothermal agent generates heat to raise the local temperature of the fibers. If the temperature is above a glass transition (Tg) of the polymer, the polymer chains will be mobile, increasing free volume in size within the shell. As a result, a rapid release of the drug can be achieved. When NIR light is turned off, the release will stop with inactivity of the photothermal agent, followed by freezing the segmental motion of the polymer chains. The on–off switching of NIR light in a time-controllable manner allows a repeated and accurate release of the drug, leading to the significant enhancement of anticancer activity in combination with the hyperthermia effect arising from the photothermal agent.