In situ effect of fluoride toothpaste supplemented with nano-sized sodium trimetaphosphate on enamel demineralization prevention and biofilm composition

•1100 F/TMPnano promoted a greater protective effect against enamel demineralization.•TMPnano affects the enamel demineralization in depth and biofilm composition.•The addition of the TMPnano toothpaste promoted a significant reduction of EPS concentration. To evaluate the effect of a fluoride tooth...

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Bibliographic Details
Published in:Archives of oral biology 2018-12, Vol.96, p.223-229
Main Authors: Emerenciano, Nayara Gonçalves, Botazzo Delbem, Alberto Carlos, Pessan, Juliano Pelim, Nunes, Gabriel Pereira, Souza Neto, Francisco Nunes, de Camargo, Emerson Rodrigues, Danelon, Marcelle
Format: Article
Language:English
Subjects:
Animals
Biofilm
Biofilms - drug effects
Caries
Cariostatic Agents - chemistry
Cariostatic Agents - pharmacology
Cattle
Cross-Over Studies
Demineralization
Dentistry
Dose-Response Relationship, Drug
Double-Blind Method
Drug Combinations
Fluoride
Fluorides, Topical - pharmacology
Hardness
Healthy Volunteers
Humans
Hydrogen-Ion Concentration
Nano-sized
Nanoparticles
Polyphosphates - pharmacology
Surface Properties
Tooth Demineralization - prevention & control
Toothpastes - chemistry
Toothpastes - pharmacology
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Summary:•1100 F/TMPnano promoted a greater protective effect against enamel demineralization.•TMPnano affects the enamel demineralization in depth and biofilm composition.•The addition of the TMPnano toothpaste promoted a significant reduction of EPS concentration. To evaluate the effect of a fluoride toothpaste containing nano-sized sodium trimetaphosphate (TMPnano) on enamel demineralization in situ and composition of the biofilm. This crossover double-blind study consisted of four phases (seven days each) and 12 volunteers who wore oral appliances containing four enamel bovine blocks. The cariogenic challenge was performed by 30% sucrose solution (6x/day). The toothpaste treatments (3x/day) were as follows: no F/TMP/TMPnano (Placebo), 1100 ppm F (1100F), 1100F plus 3% micrometric or nano-sized TMP (1100F/TMP; 1100F/TMPnano). Percentage of surface hardness loss (%SH), and integrated loss of subsurface hardness (ΔKHN), as well as enamel calcium (Ca), phosphorus (P), and fluoride (F) were determined. Moreover, biofilm formed on the blocks were analyzed for F, Ca, P, and insoluble extracellular polysaccharide (EPS) concentrations. Data were analyzed using one-way ANOVA, repeated measures followed by Fisher LSD test (p 
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2018.09.019