Effect of surgical site infection on survival after limb amputation in the curative‐intent treatment of canine appendicular osteosarcoma: a Veterinary Society of Surgical Oncology retrospective study

• Published in: Veterinary surgery 2018-11, Vol.47 (8), p.E88-E96
• Main Authors: Hans, Eric C., Pinard, Chris, van Nimwegen, S. A., Kirpensteijn, Jolle, Singh, Ameet, MacEachern, Steven, Naber, Steven, Dudley, Robert M.
• Format: Article
• Language: English
• Subjects: Amputation; Amputation - veterinary; Animals; Biocompatibility; Bone cancer; Bone Neoplasms - surgery; Bone Neoplasms - veterinary; Chemotherapy; Cohort Studies; Disease control; Disease-Free Survival; Dog Diseases - mortality; Dog Diseases - surgery; Dogs; Female; Immune system; Infections; Infectious diseases; Internship and Residency; Male; Medical records; Metastases; Ohio; Ontario; Osteosarcoma; Osteosarcoma - surgery; Osteosarcoma - veterinary; Rank tests; Regression analysis; Retrospective Studies; Societies, Veterinary; Surgery; Surgical site infections; Surgical Wound Infection - mortality; Surgical Wound Infection - veterinary; Surveys and Questionnaires; Survival; Treatment Outcome; Veterinary medicine
• ISSN: 0161-3499; 1532-950X
• DOI: 10.1111/vsu.13105

Objective To determine the influence of surgical site infection (SSI) on the median disease‐free interval (DFI) and median survival time (MST) in dogs after amputation in the curative‐intent treatment of appendicular osteosarcoma (OSA). Study design Multi‐institutional retrospective cohort study. Animals Fifteen dogs with OSA and SSI, and 134 dogs with OSA and no SSI. Methods Medical records were reviewed, and dogs were included if the following criteria were met: histologic confirmation of OSA, no evidence of metastasis, ≥1 chemotherapy treatment, and available follow‐up data. We used the definition of SSI from the Centers for Disease Control and Prevention. Kaplan‐Meier estimates of median DFI and MST for the SSI and non‐SSI groups were compared by log‐rank test. Univariate and multivariate Cox proportional hazard regression analysis was evaluated for associations with DFI and survival. Results The median DFI and MST of all OSA dogs were 236 days (95% CI, 181‐283) and 283 days (95% CI 237‐355), respectively. The median DFI of dogs with SSI (292 days) did not differ from that of dogs without SSI (224 days, P = .156). The MST of dogs with SSI (292 days) did not differ from that of dogs without SSI (280 days, P = .417). Failure to complete chemotherapy was associated with decreased DFI and survival (P