Hypocalcaemia following laryngectomy: prevalence and risk factors

To establish the prevalence of hypocalcaemia following laryngectomy and demonstrate that total thyroidectomy is a risk factor. A retrospective cohort study was conducted that included all patients who underwent total laryngectomy from 1st January 2006 to 1st August 2017. Exclusion criteria were: pre...

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Bibliographic Details
Published in:Journal of laryngology and otology 2018-11, Vol.132 (11), p.969-973
Main Authors: Harris, A S, Prades, E, Passant, C D, Ingrams, D R
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Calcium
Dissection
Ethics
Female
Humans
Hypocalcemia
Hypocalcemia - epidemiology
Hypocalcemia - etiology
Laboratories
Laryngeal cancer
Laryngectomy - adverse effects
Main Articles
Male
Medical research
Middle Aged
Odds Ratio
Otolaryngology
Parathyroid
Patients
Prevalence
Radiation therapy
Retrospective Studies
Risk Factors
Software
Surgery
Systematic review
Thyroid
Thyroid gland
Thyroidectomy
Thyroidectomy - adverse effects
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Summary:To establish the prevalence of hypocalcaemia following laryngectomy and demonstrate that total thyroidectomy is a risk factor. A retrospective cohort study was conducted that included all patients who underwent total laryngectomy from 1st January 2006 to 1st August 2017. Exclusion criteria were: pre-operative calcium derangement, previous thyroid or parathyroid surgery, concurrent glossectomy, pharyngectomy, or oesophagectomy. Ninety patients were included. Sixteen patients had early hypocalcaemia (18 per cent), seven had protracted hypocalcaemia (8 per cent) and six had permanent hypocalcaemia (10 per cent). Exact logistic regression values for hypocalcaemia following total thyroidectomy compared to other patients were: early hypocalcaemia, odds ratio = 15.5 (95 per cent confidence interval = 2.2-181.9; model p = 0.002); protracted hypocalcaemia, odds ratio = 13.3 (95 per cent confidence interval = 1.5-117.1; model p = 0.01); and permanent hypocalcaemia, odds ratio = 22.7 (95 per cent confidence interval = 1.9-376.5; model p = 0.005). This is the largest study to investigate the prevalence of hypocalcaemia following laryngectomy and the first to include follow up of longer than three months. Total thyroidectomy significantly increased the risk of hypocalcaemia at all time frames and independent of other variables.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215118001615