Endocan expression in placenta of women with hypertension

Aim The aim of our study was to determine the endocan‐1 expression in placenta of hypertensive women, and its association with maternal and fetal outcomes. Methods This was a cross‐sectional study consisted of 21 pregnant women with hypertension and 23 without hypertension. The gestational age range...

Full description

Saved in:
Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2019-02, Vol.45 (2), p.345-351
Main Authors: Chew, Bee S., Ghazali, Razmin, Othman, Hanita, Ismail, Nor A. M., Othman, Aimi S., Laim, Nur M. S. T., Wong, Yin P., Tan, Geok C.
Format: Article
Language:English
Subjects:
Adult
Birth weight
Cross-Sectional Studies
Decidua
endocan‐1
Endothelial cells
Female
Fetuses
Gestational age
Humans
Hypertension
Hypertension, Pregnancy-Induced - metabolism
Immunohistochemistry
Neoplasm Proteins - metabolism
Paraffin
Placenta
Placenta - metabolism
Preeclampsia
Pregnancy
pregnancy‐induced hypertension
Proteoglycans - metabolism
Statistical analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim The aim of our study was to determine the endocan‐1 expression in placenta of hypertensive women, and its association with maternal and fetal outcomes. Methods This was a cross‐sectional study consisted of 21 pregnant women with hypertension and 23 without hypertension. The gestational age ranged from 28 to 39 weeks (hypertensive) and 32 to 40 weeks (normotensive). The paraffin embedded formalin fixed placenta tissue blocks were retrieved from the pathology archives. Endocan immunohistochemistry was performed on tissue sections of full thickness and maternal surface of the placenta. The endocan expression was determined in fetal endothelial cells, maternal endothelial cells, cytotrophoblasts, syncytiotrophoblasts and decidual cells. The differences in endocan expression in placenta between hypertensive and normotensive subjects were evaluated by Pearson chi‐square test and t‐test were used in the statistical analysis. Results The endocan expression was significantly higher in fetal endothelial cells (P
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.13836