Lack of clastogenic/genotoxic effects of Baccharis dracunculifolia extract on Swiss mouse peripheral blood cells

Baccharis dracunculifolia De Candole (DC) (Asteraceae) is indigenous throughout southeastern Latin America and is used by local people in traditional medicine. This plant is known to be the source of resin for the highly valued Brazilian green propolis. As no information is available on the safety o...

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Bibliographic Details
Published in:Genetics and molecular research 2008-01, Vol.7 (4), p.1414-1421
Main Authors: Andrade, N.S, Perazzo, F.F, Maistro, E.L
Format: Article
Language:English
Subjects:
Animals
Asteraceae
Asteraceae - chemistry
Baccharis
Baccharis dracunculifolia
clastogenicity
Comet Assay
DNA Damage
Dose-Response Relationship, Drug
Erythrocytes - cytology
Erythrocytes - drug effects
Erythrocytes - metabolism
Female
genotoxicity
Male
medicinal plants
medicinal properties
Mice
Micronucleus Tests
plant extracts
Plant Extracts - pharmacology
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Summary:Baccharis dracunculifolia De Candole (DC) (Asteraceae) is indigenous throughout southeastern Latin America and is used by local people in traditional medicine. This plant is known to be the source of resin for the highly valued Brazilian green propolis. As no information is available on the safety of high doses of B. dracunculifolia extract, we evaluated the mutagenic potential of high doses of this plant extract in vivo on peripheral blood cells of Swiss mice using the comet assay and the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood cell samples were collected 4 and 24 h after treatment for the comet assay (genotoxicity assay), and at 48 and 72 h for the micronucleus test (clastogenicity assay). The B. dracunculifolia extract was devoid of clastogenic/genotoxic activity at all doses.
ISSN:1676-5680
1676-5680
DOI:10.4238/vol7-4gmr546