Evaluation of the Antibacterial Activity and Toxicity of 2 New Hydrogels: A Pilot Study

Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal ® and Flaminal ® Hydro (Flen Pharma, Belgi...

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Bibliographic Details
Published in:International journal of lower extremity wounds 2006-06, Vol.5 (2), p.109-114
Main Authors: Vandenbulcke, Katia, Horvat, Lada-Ivana Laenen, De Mil, Martine, Slegers, Guido, Beele, Hilde
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alginates - adverse effects
Alginates - pharmacology
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Bacterial Infections - prevention & control
Bandages, Hydrocolloid
Care and treatment
Drug Combinations
Female
Glucose Oxidase - adverse effects
Glucose Oxidase - pharmacology
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate - adverse effects
Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology
In Vitro Techniques
Keratinocytes - drug effects
Lactoperoxidase - adverse effects
Lactoperoxidase - pharmacology
Leg
Leg Ulcer - drug therapy
Leg Ulcer - microbiology
Male
Microbial Sensitivity Tests
Pilot Projects
Polyethylene Glycols - adverse effects
Polyethylene Glycols - pharmacology
Ulcers
Wound Healing - drug effects
Wounds and injuries
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Summary:Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal ® and Flaminal ® Hydro (Flen Pharma, Belgium) are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal and Flaminal Hydro were confirmed in an in vitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.
ISSN:1534-7346
1552-6941
DOI:10.1177/1534734606289507