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Evaluation of the Antibacterial Activity and Toxicity of 2 New Hydrogels: A Pilot Study
Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal ® and Flaminal ® Hydro (Flen Pharma, Belgi...
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| Published in: | International journal of lower extremity wounds 2006-06, Vol.5 (2), p.109-114 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c320t-9d91f62155dc677930174aea1ff5947f546c19394e482b3f9b263378b6be2a923 |
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| cites | cdi_FETCH-LOGICAL-c320t-9d91f62155dc677930174aea1ff5947f546c19394e482b3f9b263378b6be2a923 |
| container_end_page | 114 |
| container_issue | 2 |
| container_start_page | 109 |
| container_title | International journal of lower extremity wounds |
| container_volume | 5 |
| creator | Vandenbulcke, Katia Horvat, Lada-Ivana Laenen De Mil, Martine Slegers, Guido Beele, Hilde |
| description | Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal
® and Flaminal
® Hydro (Flen Pharma, Belgium) are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal and Flaminal Hydro were confirmed in an in vitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test. |
| doi_str_mv | 10.1177/1534734606289507 |
| format | article |
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® and Flaminal
® Hydro (Flen Pharma, Belgium) are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal and Flaminal Hydro were confirmed in an in vitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.</description><identifier>ISSN: 1534-7346</identifier><identifier>EISSN: 1552-6941</identifier><identifier>DOI: 10.1177/1534734606289507</identifier><identifier>PMID: 16698915</identifier><language>eng</language><publisher>Thousand Oaks, CA: Sage Publications</publisher><subject>Aged ; Aged, 80 and over ; Alginates - adverse effects ; Alginates - pharmacology ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Bacterial Infections - prevention & control ; Bandages, Hydrocolloid ; Care and treatment ; Drug Combinations ; Female ; Glucose Oxidase - adverse effects ; Glucose Oxidase - pharmacology ; Humans ; Hydrogel, Polyethylene Glycol Dimethacrylate - adverse effects ; Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology ; In Vitro Techniques ; Keratinocytes - drug effects ; Lactoperoxidase - adverse effects ; Lactoperoxidase - pharmacology ; Leg ; Leg Ulcer - drug therapy ; Leg Ulcer - microbiology ; Male ; Microbial Sensitivity Tests ; Pilot Projects ; Polyethylene Glycols - adverse effects ; Polyethylene Glycols - pharmacology ; Ulcers ; Wound Healing - drug effects ; Wounds and injuries</subject><ispartof>International journal of lower extremity wounds, 2006-06, Vol.5 (2), p.109-114</ispartof><rights>COPYRIGHT 2006 Sage Publications, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-9d91f62155dc677930174aea1ff5947f546c19394e482b3f9b263378b6be2a923</citedby><cites>FETCH-LOGICAL-c320t-9d91f62155dc677930174aea1ff5947f546c19394e482b3f9b263378b6be2a923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924,79235</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16698915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vandenbulcke, Katia</creatorcontrib><creatorcontrib>Horvat, Lada-Ivana Laenen</creatorcontrib><creatorcontrib>De Mil, Martine</creatorcontrib><creatorcontrib>Slegers, Guido</creatorcontrib><creatorcontrib>Beele, Hilde</creatorcontrib><title>Evaluation of the Antibacterial Activity and Toxicity of 2 New Hydrogels: A Pilot Study</title><title>International journal of lower extremity wounds</title><addtitle>Int J Low Extrem Wounds</addtitle><description>Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal
® and Flaminal
® Hydro (Flen Pharma, Belgium) are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal and Flaminal Hydro were confirmed in an in vitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alginates - adverse effects</subject><subject>Alginates - pharmacology</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Bacterial Infections - prevention & control</subject><subject>Bandages, Hydrocolloid</subject><subject>Care and treatment</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Glucose Oxidase - adverse effects</subject><subject>Glucose Oxidase - pharmacology</subject><subject>Humans</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - adverse effects</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Keratinocytes - drug effects</subject><subject>Lactoperoxidase - adverse effects</subject><subject>Lactoperoxidase - pharmacology</subject><subject>Leg</subject><subject>Leg Ulcer - drug therapy</subject><subject>Leg Ulcer - microbiology</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Pilot Projects</subject><subject>Polyethylene Glycols - adverse effects</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Ulcers</subject><subject>Wound Healing - drug effects</subject><subject>Wounds and injuries</subject><issn>1534-7346</issn><issn>1552-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp1kE1r3DAQhkVpaT7ae09Bp96caPRp5WZC2gRCW2hKj0aWpa2C10okOen--2jZhUAg6CDN6HmG4UXoC5BTAKXOQDCuGJdE0lYLot6hQxCCNlJzeL99M95s_w_QUc53hFAgWn1EByClbjWIQ_T38tFMiykhzjh6XP453M0lDMYWl4KZcGdLeAxlg8084tv4P9htUVGKf7gnfLUZU1y5KZ_jDv8KUyz4d1nGzSf0wZspu8_7-xj9-XZ5e3HV3Pz8fn3R3TSWUVIaPWrwktalRyuV0oyA4sYZ8F5orrzg0oJmmjve0oF5PVDJmGoHOThqNGXH6Otu7n2KD4vLpV-HbN00mdnFJfcUqs41VPB0B67M5Pow-1iSsfWMbh1snJ0Ptd8BF7plgrIqkJ1gU8w5Od_fp7A2adMD6bfp96_Tr8rJfpllWLvxRdjHXYFmB2Szcv1dXNJcw3l74DMmBIoc</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Vandenbulcke, Katia</creator><creator>Horvat, Lada-Ivana Laenen</creator><creator>De Mil, Martine</creator><creator>Slegers, Guido</creator><creator>Beele, Hilde</creator><general>Sage Publications</general><general>Sage Publications, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>200606</creationdate><title>Evaluation of the Antibacterial Activity and Toxicity of 2 New Hydrogels: A Pilot Study</title><author>Vandenbulcke, Katia ; Horvat, Lada-Ivana Laenen ; De Mil, Martine ; Slegers, Guido ; Beele, Hilde</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-9d91f62155dc677930174aea1ff5947f546c19394e482b3f9b263378b6be2a923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alginates - adverse effects</topic><topic>Alginates - pharmacology</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Bacterial Infections - prevention & control</topic><topic>Bandages, Hydrocolloid</topic><topic>Care and treatment</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Glucose Oxidase - adverse effects</topic><topic>Glucose Oxidase - pharmacology</topic><topic>Humans</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - adverse effects</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Keratinocytes - drug effects</topic><topic>Lactoperoxidase - adverse effects</topic><topic>Lactoperoxidase - pharmacology</topic><topic>Leg</topic><topic>Leg Ulcer - drug therapy</topic><topic>Leg Ulcer - microbiology</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Pilot Projects</topic><topic>Polyethylene Glycols - adverse effects</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Ulcers</topic><topic>Wound Healing - drug effects</topic><topic>Wounds and injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vandenbulcke, Katia</creatorcontrib><creatorcontrib>Horvat, Lada-Ivana Laenen</creatorcontrib><creatorcontrib>De Mil, Martine</creatorcontrib><creatorcontrib>Slegers, Guido</creatorcontrib><creatorcontrib>Beele, Hilde</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of lower extremity wounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vandenbulcke, Katia</au><au>Horvat, Lada-Ivana Laenen</au><au>De Mil, Martine</au><au>Slegers, Guido</au><au>Beele, Hilde</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Antibacterial Activity and Toxicity of 2 New Hydrogels: A Pilot Study</atitle><jtitle>International journal of lower extremity wounds</jtitle><addtitle>Int J Low Extrem Wounds</addtitle><date>2006-06</date><risdate>2006</risdate><volume>5</volume><issue>2</issue><spage>109</spage><epage>114</epage><pages>109-114</pages><issn>1534-7346</issn><eissn>1552-6941</eissn><abstract>Wound bed preparation remains a very important issue in wound healing. To promote the production of granulation tissue, it is necessary to remove necrotic tissue and to control infection. Necrotic tissue may be removed using a hydrogel preparation. Flaminal
® and Flaminal
® Hydro (Flen Pharma, Belgium) are 2 new hydroactive colloid gel dressings with state antibacterial properties. These properties are attributed to an enzymatic complex in their formulation. In the study described in this report, the antibacterial effects of Flaminal and Flaminal Hydro were confirmed in an in vitro as well as an in vivo setting. It was also demonstrated that Flaminal and Flaminal Hydro are not toxic to keratinocytes in vitro using an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test.</abstract><cop>Thousand Oaks, CA</cop><pub>Sage Publications</pub><pmid>16698915</pmid><doi>10.1177/1534734606289507</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1534-7346 |
| ispartof | International journal of lower extremity wounds, 2006-06, Vol.5 (2), p.109-114 |
| issn | 1534-7346 1552-6941 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21193491 |
| source | Sage Journals Online |
| subjects | Aged Aged, 80 and over Alginates - adverse effects Alginates - pharmacology Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Antibacterial agents Bacterial Infections - prevention & control Bandages, Hydrocolloid Care and treatment Drug Combinations Female Glucose Oxidase - adverse effects Glucose Oxidase - pharmacology Humans Hydrogel, Polyethylene Glycol Dimethacrylate - adverse effects Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology In Vitro Techniques Keratinocytes - drug effects Lactoperoxidase - adverse effects Lactoperoxidase - pharmacology Leg Leg Ulcer - drug therapy Leg Ulcer - microbiology Male Microbial Sensitivity Tests Pilot Projects Polyethylene Glycols - adverse effects Polyethylene Glycols - pharmacology Ulcers Wound Healing - drug effects Wounds and injuries |
| title | Evaluation of the Antibacterial Activity and Toxicity of 2 New Hydrogels: A Pilot Study |
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