Molecular study of the hematopoietic zinc finger gene in three unrelated families with gray platelet syndrome

Hematopoietic zinc finger (HZF) null mice have features reminiscent of patients with gray platelet syndrome (GPS), a rare inherited bleeding disorder. This similarity has suggested that HZF deregulation might be involved in the human disease. The sequence of the eight exons of the HZF gene as well a...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2005-09, Vol.3 (9), p.2077-2080
Main Authors: BÉNIT, L., CRAMER, E. M., MASSÉ, J. M., DUSANTER‐FOURT, I., FAVIER, R.
Format: Article
Language:English
Subjects:
Blood Platelet Disorders - genetics
Case-Control Studies
Exons
Family Health
gray platelet syndrome
hematopoietic zinc finger gene
Humans
Megakaryocytes - chemistry
platelets
Polymorphism, Genetic
RNA, Messenger - analysis
Zinc Fingers - genetics
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Summary:Hematopoietic zinc finger (HZF) null mice have features reminiscent of patients with gray platelet syndrome (GPS), a rare inherited bleeding disorder. This similarity has suggested that HZF deregulation might be involved in the human disease. The sequence of the eight exons of the HZF gene as well as the study of its expression in blood samples from five patients belonging to three different families did not reveal any modifications when compared with healthy donors. This study indicates that HZF is unlikely to be responsible for GPS.
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2005.01524.x