Aspergillus galactomannan detection: Trichoderma as a cause of positive results

Aspergillus galactomannan immunoassay is a main diagnostic and monitoring tool in medical mycology. However, the specificity of the method can be skewered by the presence of several other fungi. Trying to diagnose a possible fungal infection of the lower respiratory tract in a haematology patient, i...

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Bibliographic Details
Published in:Current microbiology 2019-01, Vol.76 (1), p.48-51
Main Authors: Markantonatou, Anthi-Marina, Samaras, Konstantinos, Yannaki, Evangelia, Zachrou, Evaggelia, Vyzantiadis, Timoleon-Achilleas
Format: Article
Language:English
Subjects:
Aspergillosis - diagnosis
Aspergillosis - microbiology
Aspergillus
Aspergillus - isolation & purification
Aspergillus - metabolism
Biomedical and Life Sciences
Biotechnology
Cell Wall - chemistry
Diagnostic software
Diagnostic systems
DNA, Ribosomal Spacer - genetics
Fungi
Immunoassay
Immunoassay - methods
Immunocompromised hosts
Invasive Fungal Infections - diagnosis
Invasive Fungal Infections - microbiology
Life Sciences
Lymphoma, Non-Hodgkin
Mannans - analysis
Microbiology
Mycology
Respiratory tract
Trichoderma
Trichoderma - isolation & purification
Trichoderma - metabolism
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Summary:Aspergillus galactomannan immunoassay is a main diagnostic and monitoring tool in medical mycology. However, the specificity of the method can be skewered by the presence of several other fungi. Trying to diagnose a possible fungal infection of the lower respiratory tract in a haematology patient, it appeared that the fungus Trichoderma longibrachiatum is an additional probable cause of positive galactomannan results. Although, that Trichoderma is a rare but emerging pathogen in immunocompromised patients, the above information could be a caution point in the clinical evaluation of diagnostic results.
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-018-1582-1