Towards Utilising Photocrosslinking of Polydiacetylenes for the Preparation of “Stealth” Upconverting Nanoparticles

We demonstrate a novel strategy for preparing hydrophilic upconverting nanoparticles (UCNPs) by harnessing the photocrosslinking ability of diacetylenes. Replacement of the hydrophobic oleate coating on the UCNPs with 10,12‐pentacosadiynoic acid, followed by overcoating with diacetylene phospholipid...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-12, Vol.57 (49), p.16036-16040
Main Authors: Nsubuga, Anne, Zarschler, Kristof, Sgarzi, Massimo, Graham, Bim, Stephan, Holger, Joshi, Tanmaya
Format: Article
Language:English
Subjects:
Biocompatibility
Coatings
crosslinking
diacetylenes
Hydrophobicity
Irradiation
lanthanides
nanomaterials
Nanoparticles
Phospholipids
Polydiacetylenes
Radiation
upconversion
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Summary:We demonstrate a novel strategy for preparing hydrophilic upconverting nanoparticles (UCNPs) by harnessing the photocrosslinking ability of diacetylenes. Replacement of the hydrophobic oleate coating on the UCNPs with 10,12‐pentacosadiynoic acid, followed by overcoating with diacetylene phospholipid and subsequent photocrosslinking under 254 nm irradiation produces water‐dispersible polydiacetylene‐coated UCNPs. These UCNPs resist the formation of a biomolecular corona and show great colloidal stability. Furthermore, amine groups on the diacetylene phospholipid allow for functionalisation of the UCNPs with, for example, radiolabels or targeting moieties. These results demonstrate that this new surface‐coating method has great potential for use in the preparation of UCNPs with improved biocompatibility. Ene‐yne incorporation: Photocrosslinkable diacetylenes can be used as surface coating agents for generating hydrophilic upconverting nanoparticles (UCNPs). After overcoating with photopolymerisable diyne phospholipids, the diyne units on the UCNP surface can be photocrosslinked by irradiation with UV light. The resulting UCNPs demonstrate “stealth” aspects, retain UC luminescence, and have active sites for attachment of bio/radioactive moieties.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201811003