Analysis of Transmission of Infection in Epidemics: Confined Random Walkers in Dimensions Higher Than One

• Published in: Bulletin of mathematical biology 2018-12, Vol.80 (12), p.3106-3126
• Main Authors: Sugaya, S., Kenkre, V. M.
• Format: Article
• Language: English
• Subjects: Animals; Cell Biology; Confining; Diffusion theory; Dimensional analysis; Epidemics; Formalism; Hantavirus; Home range; Infections; Life Sciences; Mathematical and Computational Biology; Mathematics; Mathematics and Statistics; Original Article; Rodents
• ISSN: 0092-8240; 1522-9602
• DOI: 10.1007/s11538-018-0507-2

The process of transmission of infection in epidemics is analyzed by studying a pair of random walkers, the motion of each of which in two dimensions is confined spatially by the action of a quadratic potential centered at different locations for the two walks. The walkers are animals such as rodents in considerations of the Hantavirus epidemic, infected or susceptible. In this reaction–diffusion study, the reaction is the transmission of infection, and the confining potential represents the tendency of the animals to stay in the neighborhood of their home range centers. Calculations are based on a recently developed formalism (Kenkre and Sugaya in Bull Math Biol 76:3016–3027, 2014 ) structured around analytic solutions of a Smoluchowski equation and one of its aims is the resolution of peculiar but well-known problems of reaction–diffusion theory in two dimensions. The resolution is essential to a realistic application to field observations because the terrain over which the rodents move is best represented as a 2-d landscape. In the present analysis, reaction occurs not at points but in spatial regions of dimensions larger than 0. The analysis uncovers interesting nonintuitive phenomena one of which is similar to that encountered in the one-dimensional analysis given in the quoted article, and another specific to the fact that the reaction region is spatially extended. The analysis additionally provides a realistic description of observations on animals transmitting infection while moving on what is effectively a two-dimensional landscape. Along with the general formalism and explicit one-dimensional analysis given in Kenkre and Sugaya ( 2014 ), the present work forms a model calculational tool for the analysis for the transmission of infection in dilute systems.