Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Quantum dots (QDs) are semiconductor nanoparticles ranging in size from 2 to 10 nm. QDs are increasingly being developed for biomedical imaging, targeted drug delivery and green energy technology. These have led to much research on QD interactions with various physical, chemical and biological syste...

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Bibliographic Details
Published in:Journal of biophotonics 2019-02, Vol.12 (2), p.e201800172-n/a
Main Authors: Lee, Bong H., Suresh, Sindhuja, Ekpenyong, Andrew
Format: Article
Language:English
Subjects:
Biocompatibility
Cadmium Compounds - chemistry
Cadmium selenides
Cancer
Cancer therapies
Cell Line, Tumor
Chemotherapy
Clean energy
Cytotoxicity
Daunorubicin
Daunorubicin - pharmacology
Diagnostic software
Diagnostic systems
Doxorubicin
Doxorubicin - pharmacology
Drug delivery
Drug delivery systems
Electric fields
Emission spectra
Energy technology
Fluorescence
Green energy
Humans
Medical imaging
Modulation
Nanoparticles
Optoelectronics
Organic chemistry
Properties (attributes)
quantum dot
Quantum dots
Quantum Dots - chemistry
Radiation therapy
Radiosensitization
Radiotherapy
Reactive oxygen species
Reactive Oxygen Species - metabolism
Selenium Compounds - chemistry
Spectrometry, Fluorescence
Statistical analysis
Sulfides - chemistry
Toxicity
Tumor cell lines
Zinc Compounds - chemistry
Zinc sulfide
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Summary:Quantum dots (QDs) are semiconductor nanoparticles ranging in size from 2 to 10 nm. QDs are increasingly being developed for biomedical imaging, targeted drug delivery and green energy technology. These have led to much research on QD interactions with various physical, chemical and biological systems. For biological systems, research has focused on the biocompatibility/cytotoxicity of QDs in the context of imaging/therapy. However, there is a paucity of work on how biological systems and bioactive molecules might be used to alter the optoelectronic properties of QDs. Here, it is shown that these properties can be altered by reactive oxygen species (ROS) from chemotherapeutic media and biological cells following controlled changes in cellular activities. Using CdSe/ZnS core‐shell QDs, spectroscopic analysis of optically excited QDs with HL60, K562 and T98G cancer cell lines is performed. Our results show statistically significant (P 
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201800172