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Supramolecular complexes for nanomedicine

[Display omitted] Host-guest interactions studied in supramolecular chemistry have been inspired by interactions between enzymes and substrates. Furthermore, most of the interactions involved in the cells are based on non-covalent bonds between two or more molecules. The common aspects between supra...

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Published in:Bioorganic & medicinal chemistry letters 2018-11, Vol.28 (20), p.3290-3301
Main Authors: Gangemi, Chiara M.A., Puglisi, Roberta, Pappalardo, Andrea, Trusso Sfrazzetto, Giuseppe
Format: Article
Language:English
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Summary:[Display omitted] Host-guest interactions studied in supramolecular chemistry have been inspired by interactions between enzymes and substrates. Furthermore, most of the interactions involved in the cells are based on non-covalent bonds between two or more molecules. The common aspects between supramolecular chemistry and medicine have led to the development of a “new” area called “supramolecular medicine”, in which non-covalent interactions and self-assembly processes are applied within several medical fields. The object of this Digest is to offer an account of how some macrocyclic hosts (e.g. cucurbiturils, cyclodextrins, pillararenes and calixarenes) are employed in supramolecular medicine creating new supramolecular hydrogels used as biomaterials for human tissue in regenerative medicine, and a diagnostic instrument, in-vitro and in-vivo, for the detection of diseases, as well as for the investigation of cell morphology.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2018.09.015