Topical Review Article: Brainstem and Other Malignant Gliomas: II. Possible Mechanisms of Brain Infiltration by Tumor Cells

Gliomas that arise in the brain stem and other malignant gliomas constitute approximately 60% of all brain tumors and have eluded effective therapy, in part because they are able to infiltrate the normal brain. Histopathologic studies have confirmed the presence of infiltrating tumor cells very dist...

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Bibliographic Details
Published in:Journal of Child Neurology 1993-10, Vol.8 (4), p.292-305
Main Authors: Maria, Bernard L., Eskin, Thomas A., Quisling, Ronald G.
Format: Article
Language:English
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Summary:Gliomas that arise in the brain stem and other malignant gliomas constitute approximately 60% of all brain tumors and have eluded effective therapy, in part because they are able to infiltrate the normal brain. Histopathologic studies have confirmed the presence of infiltrating tumor cells very distant from the glioma mass. We review the neuroimaging and pathologic features of glioma-cell infiltration and some of the complex cellular and biochemical determinants of tumor-cell motility and invasiveness. Understanding how glioma cells become motile and invasive is pivotal to therapeutically targeting the machinery that enables gliomas to infiltrate the brain. (J Child Neurol 1993;8:292-305).
ISSN:0883-0738
1708-8283
DOI:10.1177/088307389300800402