Influence of serum 25-hydroxyvitamin D levels, fat-free mass, and fat mass on bone density, geometry and strength, in healthy young and elderly adults

The association between serum 25-hydroxyvitamin D (25-OHD) levels and cortical/trabecular bone parameters has been explored in the elderly, but less so in younger adults; body composition may also influence bone parameters across the life span. We aimed to investigate, with peripheral quantitative c...

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Bibliographic Details
Published in:Experimental gerontology 2018-11, Vol.113, p.193-198
Main Authors: Bano, Giulia, Pigozzo, Sabrina, Piovesan, Francesca, Mazzochin, Mattia, Dianin, Marta, Bedogni, Marco, Zaninotto, Martina, Giannini, Sandro, Perissinotto, Egle, Manzato, Enzo, Plebani, Mario, Sergi, Giuseppe
Format: Article
Language:English
Subjects:
25-OHD
Absorptiometry, Photon
Adult
Aged
Body Composition
Bone Density
Bone parameters
Cross-Sectional Studies
Elderly people
Female
Healthy Volunteers
Humans
Longitudinal Studies
Male
Middle Aged
pQCT
Radius - diagnostic imaging
Tibia - diagnostic imaging
Tomography, X-Ray Computed
Vitamin D - analogs & derivatives
Vitamin D - blood
Young adults
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Summary:The association between serum 25-hydroxyvitamin D (25-OHD) levels and cortical/trabecular bone parameters has been explored in the elderly, but less so in younger adults; body composition may also influence bone parameters across the life span. We aimed to investigate, with peripheral quantitative computerized tomography (pQCT), the relationship between serum 25-OHD levels and bone geometry and strength and, at the same time, to explore the influence of fat mass and fat-free mass on bone parameters, for the tibia and radius, in healthy young and elderly adults. The study involved 149 healthy adults grouped by age: 65 were under 65 years old, and 84 were older. All participants were assessed in terms of: clinical history; serum 25-OHD levels; fat-free mass (FFM) and fat mass (FM), measured with DXA; total and cortical bone cross-sectional area (CSA, CSAc), and trabecular and cortical bone mineral density (BMDt, BMDc); and fracture load x and y for the tibia and radius, measured with pQCT. In the younger group, the association between 25-OHD levels and bone parameters did not remain as significant for any parameters after multivariate adjustment. In the elderly, 25-OHD correlated with CSAc (partial R2 = 0.33), fracture load x (partial R2 = 0.54), and fracture load y (partial R2 = 0.46) for the radius, and marginally with BMDt (partial R2 = 0.09; B-H adjusted p 
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2018.10.009