Loading…
Risk factors and therapies in vascular diseases: An umbrella review of updated systematic reviews and meta‐analyses
Aberrant blood vessel functioning and systemic circulation are key causes for vascular disorders; cardiovascular, cerebrovascular, renal artery stenosis, and peripheral artery diseases. Epidemiological and basic science evidence supported genetic reasons, compounded by obesity, hypercholesterolemia,...
Saved in:
Published in: | Journal of cellular physiology 2019-06, Vol.234 (6), p.8221-8232 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Aberrant blood vessel functioning and systemic circulation are key causes for vascular disorders; cardiovascular, cerebrovascular, renal artery stenosis, and peripheral artery diseases. Epidemiological and basic science evidence supported genetic reasons, compounded by obesity, hypercholesterolemia, hypertension, diabetes, and smoking as risk factors. This is an umbrella review of risk factors and therapies in vascular disorders, exploring systematic reviews and meta‐analyses studies in PubMed, Cochrane, Embase, and Central published in January 2000–May 2018. We made qualitative eligibility gradation of the articles based on inclusion criteria, and independently extracted descriptive and methodologic data to compile their outcomes. We considered 95% confidence interval and the between‐study heterogeneity, designated by I
2. Overall, we extracted 217 studies of impressive quality and at low risk of bias, including 124, 30, 23, 32, and 8, respectively, for the search terms “cardiovascular,” “renal,” “cerebral,” and “limb ischemia” each in combination with “risk factors” and “therapeutics.” Our search on genome‐wide analyses revealed genes associated with HDL‐cholesterol, matrix metalloproteases, angiogenesis, notch3, renin‐angiotensin, apolipoprotein E, insulin, and cytokine levels as critical participants in the pathogenesis of vascular diseases. Hypertension and endothelial growth factor‐linked polymorphisms were found to contribute to vascular damage. The studies reinforced that lifestyle and dietary patterns influenced susceptibility of circulatory system diseases. Additionally, endovascular medicines, surgical vascularization, angioplasty, and renal artery stenting appeared as major therapeutic approaches in vascular patients. Altogether, our review offers up‐to‐date information on pathophysiology of vascular diseases and provides insight into existing research, clinical management and clinical gaps in the field.
This is an umbrella review of risk factors and therapies in vascular disorders, exploring systematic reviews and meta‐analyses studies in PubMed, Cochrane, Embase and Central published in January 2000–May 2018. Overall, we extracted 217 studies of impressive quality and at low risk of bias, including 124, 30, 23, 32, and 8 respectively for the search terms “cardiovascular,” “renal,” “cerebral,” and “limb ischemia” each in combination with “risk factors” and “therapeutics.” Our review offers up‐to‐date information on pathophysiology of vascular |
---|---|
ISSN: | 0021-9541 1097-4652 1097-4652 |
DOI: | 10.1002/jcp.27633 |