Autism and Tuberous Sclerosis

The co-occurrence of autism spectrum disorder and tuberous sclerosis complex has been recognized for decades. The prevalence of tuberous sclerosis complex in the autism spectrum disorder population is 1 to 4%, whereas features of autism spectrum disorder are present in 25 to 50% of individuals with...

Full description

Saved in:
Bibliographic Details
Published in:Journal of child neurology 2004-09, Vol.19 (9), p.675-679
Main Author: Wiznitzer, Max
Format: Article
Language:English
Subjects:
Autistic Disorder - complications
Autistic Disorder - etiology
Child
Cognition Disorders - etiology
Comorbidity
Diagnosis, Differential
Humans
Tuberous Sclerosis - complications
Tuberous Sclerosis - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The co-occurrence of autism spectrum disorder and tuberous sclerosis complex has been recognized for decades. The prevalence of tuberous sclerosis complex in the autism spectrum disorder population is 1 to 4%, whereas features of autism spectrum disorder are present in 25 to 50% of individuals with tuberous sclerosis complex. The underlying reason for this association might be a nonspecific disruption of brain function owing to tuberous sclerosis complex, including tuber location, seizures and their effect on brain development, cognitive impairment, a disturbance in brain development in regions associated with autism spectrum disorder, or, less likely, a linkage between a TSC gene and an autism susceptibility gene. Awareness of the relationship between autism spectrum disorder and tuberous sclerosis complex is important during the evaluation of individuals with either disorder. Better delineation of the association and its causative factors is needed for the development of possible interventions. (J Child Neurol 2004;19:675—679).
ISSN:0883-0738
1708-8283
DOI:10.1177/08830738040190090701