Intra-individual comparison of gadolinium-enhanced MRI using pseudo-golden-angle radial acquisition with gadoxetic acid-enhanced MRI for diagnosis of HCCs using LI-RADS

• Published in: European radiology 2019-04, Vol.29 (4), p.2058-2068
• Main Authors: Kim, Yoon-Chul, Min, Ji Hye, Kim, Young Kon, Lee, Soon Jin, Ahn, Soohyun, Kim, Eunju, Peeters, Hans
• Format: Article
• Language: English
• Subjects: Acids; Adult; Aged; Blood vessels; Breathing; Carcinoma, Hepatocellular - diagnosis; Conspicuity; Contrast agents; Contrast Media - pharmacology; Data acquisition; Diagnosis; Diagnostic Radiology; Female; Gadolinium; Gadolinium DTPA - pharmacology; Ghosting; Hepatocellular carcinoma; Humans; Image acquisition; Image processing; Image quality; Imaging; Internal Medicine; Interventional Radiology; Liver; Liver Neoplasms - diagnosis; Magnetic Resonance; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical diagnosis; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Neuroradiology; NMR; Nuclear magnetic resonance; Prospective Studies; Radiology; Reproducibility of Results; Respiration; ROC Curve; Sharpness; Tumors; Ultrasound
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-018-5771-x

Objectives To determine the usefulness of extracellular contrast agent (ECA)-enhanced multiphasic liver magnetic resonance imaging (MRI) using a pseudo-golden-angle radial acquisition scheme by intra-individual comparison with gadoxetic acid-MRI (EOB-MRI) with regard to image quality and the diagnosis of hepatocellular carcinoma (HCC). Materials and methods This prospective study enrolled 15 patients with 18 HCCs who underwent EOB-MRI using a Cartesian approach and ECA-MRI using the pseudo-golden-angle radial acquisition scheme (free-breathing continuous data acquisition for 64 s following ECA injection, generating six images). Two reviewers evaluated the arterial and portal phases of each MRI for artifacts, organ sharpness, and conspicuity of intrahepatic vessels and the hepatic tumors. A Liver Imaging Reporting and Data System category was also assigned to each lesion. Results There were no differences in the subjective image quality analysis between the arterial phases of two MRIs ( p  > 0.05). However, ghosting artifact was seen only in EOB-MRI ( N  = 3). Six HCCs showed different signal intensities in the arterial phase or portal phase between the two MRIs; five HCCs showed arterial hyperenhancement on ECA-MRI, but not on EOB-MRI. The capsule was observed in 15 HCCs on ECA-MRI and 6 HCCs on EOB-MRI. Five and one HCC were assigned as LR-5 and LR-4 with ECA-MRI and LR-4 and LR-3 with EOB-MRI, respectively. Conclusion Free-breathing ECA-enhanced multiphasic liver MRI using a pseudo-golden-angle radial acquisition was more sensitive in detecting arterial hyperenhancement of HCC than conventional EOB-MRI, and the image quality was acceptable. Key Points • The pseudo-golden-angle radial acquisition scheme can be applied to perform free-breathing multiphasic dynamic liver MRI. • Adopting the pseudo-golden-angle radial acquisition scheme can improve the detection of arterial enhancement of HCC. • The pseudo-golden-angle radial acquisition scheme enables motion-free liver MRI.