Correlation between the Trofile super(+) test and virological response to a short-term maraviroc exposure in HIV-infected patients

Objectives The current validated assay to determine tropism of HIV variants is Trofile super(+), which has some limitations. The aim of this work was to correlate the virological response to a short-term maraviroc exposure with Trofile super(+).Methods From 1 July 2008 to 1 March 2009, 34 consecutiv...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2009-10, Vol.64 (4), p.845-849
Main Authors: Genebat, Miguel, Ruiz-Mateos, Ezequiel, Leon, Juan A, Gonzalez-Serna, Alejandro, Pulido, Ildefonso, Rivas, Inmaculada, Ferrando-Martinez, Sara, Sanchez, Berta, Munoz-Fernandez, Ma Angeles, Leal, Manuel
Format: Article
Language:English
Subjects:
Human immunodeficiency virus
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Summary:Objectives The current validated assay to determine tropism of HIV variants is Trofile super(+), which has some limitations. The aim of this work was to correlate the virological response to a short-term maraviroc exposure with Trofile super(+).Methods From 1 July 2008 to 1 March 2009, 34 consecutive HIV-infected patients with detectable viral load during the last 6 months began an 8 day exposure to maraviroc (MCT group); six HIV-infected patients without antiretroviral therapy received no treatment (control group). Plasma viral load was evaluated on days 0, 2, 5 and 8. Baseline Trofile super(+) was performed in MCT group patients. The maraviroc clinical test (MCT) was considered positive if viral load was undetectable (
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkp293