Alginate-chitosan microspheres for the specific sorption of antibodies

Potentially hemocompatible alginate-chitiosan microparticles and microcapsules coated with a semipermeable membrane with incorporated glycoconjugates were synthesized. The membrane acts as a barrier, which keeps the incorporated glycoconjugate from going outside but permits antibodies to penetrate i...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2008-07, Vol.34 (4), p.468-474
Main Authors: Selina, O. E., Chinarev, A. A., Obukhova, P. S., Bartkowiak, A., Bovin, N. V., Markvicheva, E. A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Organic Chemistry
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Summary:Potentially hemocompatible alginate-chitiosan microparticles and microcapsules coated with a semipermeable membrane with incorporated glycoconjugates were synthesized. The membrane acts as a barrier, which keeps the incorporated glycoconjugate from going outside but permits antibodies to penetrate inside and specifically bind to antigens, high-molecular polysaccharide conjugates. The supports obtained are highly competitive in sorption capacity with Sepharose modified by the same oligosaccharides.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162008040110