Neuroimmunity, drugs of abuse, and neuroAIDS

It has long been postulated that drugs of abuse may represent significant cofactors in the progression of human immunodeficiency virus (HIV)-induced disease. Both HIV infection and drugs of abuse have significant effect on the immune system as well as on the nervous system. In HIV infection, abnorma...

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Bibliographic Details
Published in:Journal of neuroimmune pharmacology 2006-03, Vol.1 (1), p.41-49
Main Authors: Burdo, Tricia H, Katner, Simon N, Taffe, Michael A, Fox, Howard S
Format: Article
Language:English
Subjects:
AIDS Dementia Complex - epidemiology
AIDS Dementia Complex - immunology
AIDS Dementia Complex - physiopathology
Animals
Brain - drug effects
Brain - virology
Drugs
HIV
Human immunodeficiency virus
Humans
Models, Immunological
Models, Neurological
Nervous system
Neuroimmunomodulation - physiology
Primates
Simian immunodeficiency virus
Substance-Related Disorders - epidemiology
Substance-Related Disorders - immunology
Substance-Related Disorders - physiopathology
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Summary:It has long been postulated that drugs of abuse may represent significant cofactors in the progression of human immunodeficiency virus (HIV)-induced disease. Both HIV infection and drugs of abuse have significant effect on the immune system as well as on the nervous system. In HIV infection, abnormalities in these systems intersect to lead to a constellation of symptoms known as neuroAIDS. Drugs of abuse may synergize with such damage, acting on immune and/or neural cells. However, definitive epidemiological evidence for such an interaction is lacking. Here we review such studies as well as the use of the nonhuman primate/simian immunodeficiency virus system to investigate the interaction of neuroAIDS with drugs of abuse. Furthermore, recent findings on mechanisms of actions of selected drugs reveal the possibility of protective as well as detrimental effects on the central nervous system damage induced by HIV.
ISSN:1557-1890
1557-1904
DOI:10.1007/s11481-005-9001-3