In vivo and in vitro assessment of the bleaching effectiveness of a brush-off patch containing 3.0% hydrogen peroxide

• Published in: Clinical oral investigations 2019-06, Vol.23 (6), p.2667-2673
• Main Authors: Jung, Yun-Sook, Jo, Hwa-Young, Ahn, Jae-Hyun, Kim, Ji Young, Jin, Myoung-Uk, Cho, Min-Jeong, Choi, Youn-Hee, Song, Keun-Bae
• Format: Article
• Language: English
• Subjects: Adult; Bleaching; Color; Cosmetic dentistry; Dentistry; Female; Humans; Hydrogen peroxide; Hydrogen Peroxide - administration & dosage; Hydroxyapatite; Medicine; Original Article; Teeth; Tooth Bleaching; Tooth Bleaching Agents - administration & dosage; Tooth Discoloration; Toothbrushes; Treatment Outcome
• ISSN: 1432-6981; 1436-3771
• DOI: 10.1007/s00784-018-2675-8

Objectives To evaluate the efficacy of a brush-off patch containing 3.0% hydrogen peroxide, which is a new over-the-counter (OTC) product for tooth whitening, and determine the optimal protocol for use. Materials and methods We performed an in vitro study using hydroxyapatite specimens and a clinical trial involving 140 volunteers. The brush-off patch was applied to the specimens (in vitro) or the maxillary anterior teeth (in vivo; 14 days) for 10 min twice daily (case 10 group) or 30 min once daily (case 30 group). We also included control groups in both experiments. Lightness ( L *), redness ( a *), and yellowness ( b *) values were measured using a colorimeter. In the in vivo study, color changes were measured at baseline and 7 and 14 days after the start of patch application. The overall color change (Δ E ) was statistically analyzed. Results In the in vitro study, the color change (Δ E *) after the experiment was significantly different between the two case groups and the control group ( p