Oxytocin infusion reduces bleeding during abdominal myomectomies: a randomized controlled trial

• Published in: Archives of gynecology and obstetrics 2019-01, Vol.299 (1), p.151-157
• Main Authors: Aslan Çetin, Berna, Aydoğan Mathyk, Begüm, Köroğlu, Nadiye, Soydar, Ali, Demirayak, Gökhan, Çift, Tayfur
• Format: Article
• Language: English
• Subjects: Abdomen; Abdomen - surgery; Adult; Blood; Blood Loss, Surgical - prevention & control; Blood transfusions; Clinical trials; Double-Blind Method; Endocrinology; Female; Fibroids; General Gynecology; Gynecology; Hemoglobin; Human Genetics; Humans; Hysterectomy; Infusions, Parenteral; Leiomyoma - pathology; Leiomyoma - surgery; Medicine; Medicine & Public Health; Obstetrics; Obstetrics/Perinatology/Midwifery; Oxytocics - administration & dosage; Oxytocin - administration & dosage; Oxytocin - therapeutic use; Performance evaluation; Regression analysis; Software; Surgery; Treatment Outcome; Turkey; Uterine Myomectomy - methods; Uterine Neoplasms - pathology; Uterine Neoplasms - surgery
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-018-4944-9

Purpose To evaluate the effectiveness of oxytocin infusion to reduce intraoperative bleeding during abdominal myomectomies. Methods This randomized, parallel group, blinded study was conducted between October 2017 and May 2018. Patients undergoing abdominal myomectomies were randomized 1:1 either to the oxytocin group or to the control group (saline). In the oxytocin group, 10 IU oxytocin in 500 ml of saline at a rate of 120 ml/h was given during the course of the operation. The primary outcome of this study was to measure intraoperative blood loss between the study groups. Correlation and multiple regression analysis were performed to illustrate factors associated with intraoperative blood loss during the myomectomy. Results The mean intraoperative blood loss during the surgery was 489.20 ± 239.72 ml in the oxytocin group and was 641.40 ± 288.21 ml in the control group. The hemoglobin decline was more evident in the control group than in the oxytocin group. Positive correlations were also observed between the intraoperative blood loss and number of fibroids removed during the surgery, largest fibroid removed and weight of fibroids removed. The use of oxytocin infusion during the myomectomy resulted in a reduction of bleeding in the regression model. Conclusion Intravenous oxytocin infusion is a safe and practical method to reduce intraoperative blood loss during the abdominal myomectomy.