Bioactive triterpenes from Diospyros blancoi

The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of α-amyrin palmitate, α-amyrin palmitoleate, β-amyrin palmitate and β-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were el...

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Bibliographic Details
Published in:Natural product research 2009-01, Vol.23 (13), p.1252-1258
Main Authors: Ragasa, Consolacion Y., Puno, Marc Rhyan Anthony, Sengson, Josephine Marie Angeline P., Shen, Chien-Chang, Rideout, John A., Raga, Dennis D.
Format: Article
Language:English
Subjects:
analgaesic
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
anti-inflammatory
antimicrobial
Aspergillus niger
Aspergillus niger - drug effects
Bacillus subtilis
Bacillus subtilis - drug effects
Bacteria - drug effects
Candida albicans
Candida albicans - drug effects
Diospyros - chemistry
Diospyros blancoi
Ebenaceae
Escherichia coli
Escherichia coli - drug effects
Fungi - drug effects
isoarborinol methyl ether
Microbial Sensitivity Tests
Molecular Structure
Pseudomonas aeruginosa
Staphylococcus aureus
Staphylococcus aureus - drug effects
Trichophyton - drug effects
Trichophyton mentagrophytes
Triterpenes - chemistry
Triterpenes - pharmacology
α-amyrin palmitate
β-amyrin palmitate
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Summary:The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of α-amyrin palmitate, α-amyrin palmitoleate, β-amyrin palmitate and β-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410902951054