Evaluation Of A Human Immunometric Assay For The Determination Of Thyroid-Stimulating Hormone In Nonhuman Primates

Sera from nine species of clinically healthy nonhuman primates were assayed for T4 and thyroid-stimulating hormone (TSH) using human immunoassays (a fluorescence polarization immunoassay for T4, a microparticle enzyme immunoassay for TSH). The T4 levels ranged from 20 to 132 nmol/L ([xmacr] c SD = 6...

Full description

Saved in:
Bibliographic Details
Published in:Journal of zoo and wildlife medicine 2000-06, Vol.31 (2), p.267-268
Main Authors: Lair, S, Crawshaw, G J, Mehren, K G, Perrone, MA
Format: Article
Language:English
Subjects:
Ateles
Gorilla gorilla gorilla
Lemur
Leontopithecus
Macaca
Papio
Pongo pygmaeus abelii
Primates
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sera from nine species of clinically healthy nonhuman primates were assayed for T4 and thyroid-stimulating hormone (TSH) using human immunoassays (a fluorescence polarization immunoassay for T4, a microparticle enzyme immunoassay for TSH). The T4 levels ranged from 20 to 132 nmol/L ([xmacr] c SD = 62.8 c 24.7 nmol/L). Levels of TSH were detected only in western lowland gorillas (Gorilla gorilla gorilla ) and Sumatran orang-utans (Pongo pygmaeus abelii ) (range, 0.4-10.8 mIU/L; detectable limit = 0.01 mIU/L). The results suggest that the antibodies used in the commercial TSH immunoassay assessed in this study cross-react with gorilla and orang-utan TSH but not with TSH of primates of the genera Macaca, Papio, Erythrocebus, Ateles, Leontopithecus, and Lemur.
ISSN:1042-7260
DOI:10.1043/1042-7260(2000)031(0267:EOAHIA)2.0.CO;2