Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea

The root extract from Rhodiola rosea has been reported to have numerous health benefits in human and animal studies. Its molecular mechanism is currently unknown; however, it has been suggested to act as an antioxidant. This study found that a formulation of R. rosea extract, SHR-5, from the Swedish...

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Bibliographic Details
Published in:Free radical research 2009-09, Vol.43 (9), p.836-843
Main Authors: Schriner, Samuel E, Abrahamyan, Ani, Avanessian, Agnesa, Bussel, Irvin, Maler, Steven, Gazarian, Maral, Holmbeck, Marissa A, Jafari, Mahtab
Format: Article
Language:English
Subjects:
Animals
Antioxidants - chemistry
Antioxidants - pharmacology
Catalase - metabolism
Cytoprotection
Disaccharides - analysis
Down-Regulation
Drosophila melanogaster
Drosophila melanogaster - drug effects
Drosophila melanogaster - metabolism
Female
Fertility - drug effects
Glucosides - analysis
Hydrogen Peroxide - toxicity
Longevity - drug effects
Male
Mitochondria - drug effects
Mitochondria - enzymology
Mitochondria - metabolism
Oxidants - toxicity
Oxidative Stress - drug effects
Paraquat - toxicity
Phenols - analysis
Plant Extracts - pharmacology
Plant Roots
Rhodiola
Superoxide Dismutase - metabolism
Superoxides - metabolism
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Summary:The root extract from Rhodiola rosea has been reported to have numerous health benefits in human and animal studies. Its molecular mechanism is currently unknown; however, it has been suggested to act as an antioxidant. This study found that a formulation of R. rosea extract, SHR-5, from the Swedish Herbal Institute (SHI) could extend both mean (24% in both sexes) and maximum (16% in males and 31% in females) life span in Drosophila melanogaster when compared to controls. It also found that it lowered mitochondrial superoxide levels and afforded elevated protection against the superoxide generator paraquat in both sexes. The extract SHR-5 did not alter the activities of the major antioxidant enzymes, the superoxide dismutases or catalase, nor did it afford protection against H(2)O(2) or soluble iron. These results present a decrease in endogenous superoxide levels as a possible mode of action for the root extract of R. rosea.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760903089724