The particular relationship between Parkinson’s disease and malignancy: a focus on skin cancers

Although the risk for most cancers appears to be relatively low in patients with Parkinson’s disease (PD), skin cancers and melanomas occur more frequently in the PD population as compared to controls. This article summarizes the findings of cohort studies on skin cancer in Parkinson’s disease. Give...

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Bibliographic Details
Published in:Journal of Neural Transmission 2009-11, Vol.116 (11), p.1503-1507
Main Authors: Inzelberg, Rivka, Israeli-Korn, Simon D.
Format: Article
Language:English
Subjects:
Antiparkinson Agents - adverse effects
Basic Neurosciences
Causality
Comorbidity
Genetics and Immunology - Review Article
Humans
Levodopa - adverse effects
Mass Screening
Medicine
Medicine & Public Health
Melanoma - epidemiology
Melanoma - etiology
Melanoma - physiopathology
Neurology
Neurosciences
Parkinson Disease - drug therapy
Parkinson Disease - epidemiology
Parkinson Disease - physiopathology
Psychiatry
Risk Factors
Skin Neoplasms - epidemiology
Skin Neoplasms - etiology
Skin Neoplasms - physiopathology
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Summary:Although the risk for most cancers appears to be relatively low in patients with Parkinson’s disease (PD), skin cancers and melanomas occur more frequently in the PD population as compared to controls. This article summarizes the findings of cohort studies on skin cancer in Parkinson’s disease. Given that melanoma may precede use of l -dopa, the increased risk of melanoma for PD patients cannot be attributed to l -dopa. On the basis of these observations it may be reasonable to recommend that all patients with PD, whether treated with l -dopa or not, should undergo regular dermatological screening for neoplastic or pre-neoplastic skin lesions, especially melanoma.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-009-0322-x