Effect of Paired Associative Stimulation on Motor Cortex Excitability in Rats

Paired associative stimulation (PAS), combining transcranial magnetic stimulation (TMS) with electrical peripheral nerve stimulation (PNS) in pairs with an optimal interstimulus interval (ISI) in between, has been shown to influence the excitability of the motor cortex (MC) in humans. However, the u...

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Bibliographic Details
Published in:Current medical science 2018-10, Vol.38 (5), p.903-909
Main Authors: Zhang, Xiang-yu, Sui, Yan-fang, Guo, Tie-cheng, Wang, Sai-hua, Hu, Yan, Lu, Yin-shan
Format: Article
Language:English
Subjects:
Animals
Electric Stimulation
Evoked Potentials, Motor - physiology
Evoked Potentials, Somatosensory - physiology
Humans
Long-Term Potentiation - physiology
Male
Medicine
Medicine & Public Health
Motor Cortex - physiology
Muscle, Skeletal - physiology
Neuronal Plasticity - physiology
Rats
Rats, Sprague-Dawley
Reaction Time - physiology
Transcranial Magnetic Stimulation
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Summary:Paired associative stimulation (PAS), combining transcranial magnetic stimulation (TMS) with electrical peripheral nerve stimulation (PNS) in pairs with an optimal interstimulus interval (ISI) in between, has been shown to influence the excitability of the motor cortex (MC) in humans. However, the underlying mechanisms remain unclear. This study was designed to explore an optimal protocol of PAS, which can modulate the excitability of MC in rats, and to investigate the underlying mechanisms. The resting motor thresholds (RMTs) of TMS-elicited motor evoked potentials (MEPs) recorded from the gastrocnemius muscle and the latency of P1 component of somatosensory evoked potentials (SEPs) induced by electrical tibial nerve stimulation were determined in male Sprague-Dawley rats ( n =10). Sixty rats were then randomly divided into 3 groups: a PAS group (further divided into 10 subgroups at various ISIs calculated by using the latency of P1, n =5, respectively), a TMS (only) group ( n =5) and a PNS (only) group ( n =5). Ninety repetitions of PAS, TMS and PNS were administered to the rats in the 3 groups, respectively, at the frequency of 0.05 Hz and the intensity of TMS at 120% RMT and that of PNS at 6 mA. RMTs and motor evoked potentials’ amplitude (MEPamp) were recorded before and immediately after the interventions. It was found that the MEPamp significantly decreased after PAS at ISI of 5 ms ( P
ISSN:2096-5230
2523-899X
DOI:10.1007/s11596-018-1960-8