A Retrospective Analysis of Intracranial Hemorrhage in Children with Hemophilia A

• Published in: Current medical science 2018-10, Vol.38 (5), p.875-879
• Main Authors: Hu, Qun, Zhang, Ai, Liu, Ai-guo, Wang, Song-mi, Wang, Ya-qin, Zhang, Liu-qing
• Format: Article
• Language: English
• Subjects: Child; Child, Preschool; China; Craniocerebral Trauma - complications; Craniocerebral Trauma - diagnostic imaging; Craniocerebral Trauma - drug therapy; Craniocerebral Trauma - physiopathology; Factor VIII - administration & dosage; Female; Hematoma - complications; Hematoma - diagnostic imaging; Hematoma - drug therapy; Hematoma - physiopathology; Hemophilia A - complications; Hemophilia A - diagnostic imaging; Hemophilia A - drug therapy; Hemophilia A - physiopathology; Humans; Infant; Intracranial Hemorrhages - complications; Intracranial Hemorrhages - diagnostic imaging; Intracranial Hemorrhages - drug therapy; Intracranial Hemorrhages - physiopathology; Male; Medicine; Medicine & Public Health; Retrospective Studies; Risk Factors; Tomography, X-Ray Computed
• ISSN: 2096-5230; 2523-899X
• DOI: 10.1007/s11596-018-1956-4

To investigate the incidence, risk factors, clinical manifestations and prognosis of intracranial hemorrhage (ICH) in children with hemophilia A in a center of China, we conducted a retrospective analysis of 126 children with hemophilia A at our hospital in recent 4 years. Thirty-six children with hemophilia A (including 19 severe cases, and 17 moderate cases complicated with joint diseases) received low dose factor VIII (FVIII) prophylaxis, and none of them had ICH. However, 13 cases of hemophilia A not given prophylaxis were complicated with ICH (12 severe cases, and 1 moderate case) and demonstrated an incidence of 10.3% (13/126) in all patients, and 28.6% (12/42) in severe cases. Of the 13 cases, 9 severe ICH cases had a definite history of head injury, accounting for 69.2%. Headache was common in children >3 years, but somnolence, irritability, gaze or convulsions in children