Response to ustekinumab in three pediatric patients with alopecia areata

Alopecia areata (AA) is relatively common and can have a significant impact on quality of life, especially in a pediatric population. Currently available treatments are often ineffective or have poor safety profiles. Recent studies have highlighted the importance of the Th1 pathway in the pathogenes...

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Bibliographic Details
Published in:Pediatric dermatology 2019-01, Vol.36 (1), p.e44-e45
Main Authors: Aleisa, Abdullah, Lim, Yeun, Gordon, Samantha, Her, Min Ji, Zancanaro, Pedro, Abudu, Minawaer, Deverapalli, Sandhya Chowdary, Madani, Abdulaziz, Rosmarin, David
Format: Article
Language:English
Subjects:
Alopecia
alopecia areata
Baldness
Case reports
Hair loss
Immunotherapy
Lymphocytes T
Monoclonal antibodies
Pathogenesis
Patients
pediatric
Pediatrics
Quality of life
treatment
ustekinumab
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Summary:Alopecia areata (AA) is relatively common and can have a significant impact on quality of life, especially in a pediatric population. Currently available treatments are often ineffective or have poor safety profiles. Recent studies have highlighted the importance of the Th1 pathway in the pathogenesis of AA, suggesting ustekinumab as a treatment modality for this disease. We present three pediatric AA patients who demonstrated hair regrowth after initiating ustekinumab.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.13699