Tumor-Targeted Quantum Dots Can Help Surgeons Find Tumor Boundaries

Despite surgical advances and recent progress in adjuvant therapies, the prognosis for patients with malignant brain tumors such as glioblastoma multiforme has remained poor, and the neurological deterioration suffered by most patients as a consequence of tumor progression is dramatic and severe. In...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on nanobioscience 2009-03, Vol.8 (1), p.65-71
Main Authors: Arndt-Jovin, Donna J., Kantelhardt, Sven R., Caarls, Wouter, de Vries, Anthony H. B., Giese, Alf, Jovin, Thomas M.
Format: Magazinearticle
Language:English
Subjects:
Animals
Antibodies, Monoclonal - pharmacokinetics
Brain cancer
Brain modeling
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Cancer
Cell Line, Tumor
Cellular imaging
confocal microscopy
epidermal growth factor (EGF)
Epidermal Growth Factor - pharmacokinetics
epidermal growth factor receptor (EGFR)
Epidermis
experimental intraoperative imaging
extent of resection
glioma
Glioma - metabolism
Glioma - pathology
Humans
Image Enhancement - methods
Medical treatment
Mice
Microscopy, Fluorescence - methods
Molecular Probe Techniques
Neoplasms
programmable array microscope (PAM) microscopy
Quantum Dots
Sensitivity and Specificity
Surgery
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite surgical advances and recent progress in adjuvant therapies, the prognosis for patients with malignant brain tumors such as glioblastoma multiforme has remained poor, and the neurological deterioration suffered by most patients as a consequence of tumor progression is dramatic and severe. In addition, malignant brain tumors have > 95% recurrence close to the primary site of initial resection. Unfortunately, standard imaging techniques do not permit the intraoperative identification of individual or small clusters of residual tumor cells, precluding their selective removal while sparing the surrounding normal brain tissue. In this report, we show that quantum dots (QDs) coupled to epidermal growth factor (EGF) or anti-EGF receptor (EGFR, Her1) specifically and sensitively label glial tumor cells in cell culture, glioma mouse models, and human brain-tumor biopsies. A clear demarcation between brain and tumor tissue at the macroscopic as well as the cellular level is provided by the fluorescence emission of the QDs.
ISSN:1536-1241
1558-2639
DOI:10.1109/TNB.2009.2016548