Gastric GIST Incidentally Detected on 68Ga-PSMA-PET/CT: Correlation Between Functional Imaging and Histology

ABSTRACTProstate-specific membrane antigen (PSMA) is specific for prostate cancer cells; nevertheless when finding uptake in abnormal locations for prostate cancer metastases, it is important to consider other hypothesis, including second cancers. There are several papers about PSMA expression in ma...

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Bibliographic Details
Published in:Clinical nuclear medicine 2018-12, Vol.43 (12), p.e488-e491
Main Authors: Vaz, Sofia, Oliveira, Carla, Castanheira, Joana C, Silva, Ângelo F, Costa, Durval C
Format: Article
Language:English
Subjects:
Aged
Edetic Acid - analogs & derivatives
Gastrointestinal Stromal Tumors - diagnostic imaging
Gastrointestinal Stromal Tumors - pathology
Humans
Incidental Findings
Male
Oligopeptides
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - pathology
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Summary:ABSTRACTProstate-specific membrane antigen (PSMA) is specific for prostate cancer cells; nevertheless when finding uptake in abnormal locations for prostate cancer metastases, it is important to consider other hypothesis, including second cancers. There are several papers about PSMA expression in many different types of cancer, but few reported expression in gastrointestinal stromal tumors (GIST). In this case, we documented the GIST lesion not only by PET/CT but also by gastroscopy and histology. Additionally, PSMA immunochemistry was performed, showing PSMA expression in tumoral GIST cells (not in endothelial cells), evidencing a good correlation between PET/CT image and histology.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000002347