Risk of Nursing Home Admission in Cerebral Small Vessel Disease

• Published in: Stroke (1970) 2018-11, Vol.49 (11), p.2659-2665
• Main Authors: Bergkamp, Mayra I, Wissink, Joost G J, van Leijsen, Esther M C, Ghafoorian, Mohsen, Norris, David G, van Dijk, Ewoud J, Platel, Bram, Tuladhar, Anil M, de Leeuw, Frank-Erik
• Format: Article
• Language: English
• ISSN: 1524-4628
• DOI: 10.1161/STROKEAHA.118.021993

Background and Purpose- Since cerebral small vessel disease (SVD) is associated with cognitive and motor impairment and both might ultimately lead to nursing home admission, our objective was to investigate the association of SVD markers with nursing home admission. Methods- The RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort) is a prospective cohort of 503 independent living individuals with SVD. Date of nursing home admission was retrieved from the Dutch municipal personal records database. Risk of nursing home admission was calculated using a competing risk analysis, with mortality as a competing risk. Results- During follow-up (median 8.7 years, interquartile range 8.5-8.9), 31 participants moved to a nursing home. Before nursing home admission, 19 participants were diagnosed with dementia, 6 with parkinsonism, and 10 with stroke. Participants with the lowest white matter volume had an 8-year risk of nursing home admission of 13.3% (95% CI, 8.6-18.9), which was significantly different from participants with middle or highest white matter volume (respectively, 4.8% [95% CI, 2.3-8.8] and 0%; P