Concentrations of Gaseous Transmitters during Catecholamine Damage to the Myocardium in Rats

Gaseous transmitters were assayed in rat blood during catecholamine-induced damage to the heart. Hypercatecholaminemia was modeled by single subcutaneous injection of 0.1% epinephrine hydrochloride in a dose of 2 mg/kg. The blood concentrations of NO, H 2 S, and CO were measured. The catecholamine-i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-10, Vol.165 (6), p.725-727
Main Authors: Ivanova, A. S., Sitnikova, O. G., Popova, I. G., Nazarov, S. B.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood levels
Carbon Monoxide - blood
Catecholamines
Catecholamines - adverse effects
Cell Biology
Epinephrine
Epinephrine - pharmacology
Heart - drug effects
Hydrogen sulfide
Hydrogen Sulfide - blood
Injection
Internal Medicine
Laboratory Medicine
Male
Myocardium
Myocardium - metabolism
Nitric Oxide - blood
Pathology
Rats
Rats, Wistar
Signal Transduction
Time Factors
Transmitters
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Summary:Gaseous transmitters were assayed in rat blood during catecholamine-induced damage to the heart. Hypercatecholaminemia was modeled by single subcutaneous injection of 0.1% epinephrine hydrochloride in a dose of 2 mg/kg. The blood concentrations of NO, H 2 S, and CO were measured. The catecholamine-induced damage to the myocardium resulted in phasic changes in the blood levels of gaseous transmitters: CO concentration increased in 1 h, H 2 S increased in 24 h, and NO concentration increased in 72 h after injection.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4251-2