Chronopharmacological Characteristics of the Effect of Hepatoprotectors in Experiment?

We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-10, Vol.165 (6), p.754-757
Main Authors: Bunyatyan, N. D., Kal’ko, E. A., Drogovoz, S. M., Kononenko, A. V.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Carbamates - pharmacology
Cell Biology
Circadian Rhythm - drug effects
Circadian rhythms
Female
Glutarates - pharmacology
Glutathione - metabolism
Hepatitis
Internal Medicine
Laboratory Medicine
Liver - drug effects
Liver - metabolism
Organometallic Compounds - pharmacology
Oxidative Stress
Paracetamol
Pathology
Rats
Silymarin - pharmacology
Time Factors
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Summary:We studied circadian rhythms of activity of hepatoprotectors (Antral, Carsil, and glutargin) under conditions of acute paracetamol-induced hepatitis simulated in the morning, afternoon, evening, and at night (09.00, 15.00, 21.00, and 03.00). Antral and Carsil exhibited similar chronoprofiles with the maximum hepatoprotective activity at 09.00 and 21.00, while glutargin exhibited circadian pattern opposite and its activity was maximum at 15.00 and 03.00.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4258-8