Reversible paclitaxel-induced vocal cord paralysis with later recall with vinorelbine

Described is the first reported case of paclitaxel-induced recurrent laryngeal nerve paralysis in a patient receiving adjuvant therapy for breast cancer. This rare form of neuropathy was reversible at 3 months, but it was re-induced 11 months later when the patient received vinorelbine.

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 2008-02, Vol.61 (2), p.345-346
Main Authors: Choi, Brian S., Robins, H. Ian
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
Biological and medical sciences
Breast Neoplasms - complications
Breast Neoplasms - drug therapy
Cancer Research
Carcinoma, Ductal, Breast - complications
Carcinoma, Ductal, Breast - drug therapy
Female
Humans
Laryngeal Nerves - physiopathology
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Metastasis
Neurotoxicity Syndromes - physiopathology
Oncology
Paclitaxel - adverse effects
Paclitaxel - therapeutic use
Peripheral Nervous System Diseases - chemically induced
Peripheral Nervous System Diseases - physiopathology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Recurrence
Short Communication
Vinblastine - adverse effects
Vinblastine - analogs & derivatives
Vinblastine - therapeutic use
Vocal Cord Paralysis - chemically induced
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Description
Summary:Described is the first reported case of paclitaxel-induced recurrent laryngeal nerve paralysis in a patient receiving adjuvant therapy for breast cancer. This rare form of neuropathy was reversible at 3 months, but it was re-induced 11 months later when the patient received vinorelbine.
ISSN:0344-5704
1432-0843
DOI:10.1007/s00280-007-0453-4