Multiple antidiabetic effects of three α-glucosidase inhibitory peptides, PFP, YPL and YPG: Dipeptidyl peptidase–IV inhibition, suppression of lipid accumulation in differentiated 3T3-L1 adipocytes and scavenging activity on methylglyoxal

Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; dipeptidyl peptidase-IV inhibition (DPP-IV), lipid accumulation and the differen...

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Bibliographic Details
Published in:International journal of biological macromolecules 2019-02, Vol.122, p.104-114
Main Authors: Ibrahim, Mohammed Auwal, Serem, June C., Bester, Megan J., Neitz, Albert W., Gaspar, Anabella R.M.
Format: Article
Language:English
Subjects:
3T3-L1 Cells
Adipocyte differentiation
Adipocytes - cytology
Adipocytes - drug effects
alpha-Glucosidases - metabolism
Amino Acid Sequence
Animals
Antioxidant activity
Cell Differentiation - drug effects
Dipeptidyl peptidase IV inhibition
Dipeptidyl-Peptidase IV Inhibitors - chemistry
Dipeptidyl-Peptidase IV Inhibitors - metabolism
Dipeptidyl-Peptidase IV Inhibitors - pharmacology
Free Radical Scavengers - chemistry
Free Radical Scavengers - metabolism
Free Radical Scavengers - pharmacology
Glycoside Hydrolase Inhibitors - chemistry
Glycoside Hydrolase Inhibitors - metabolism
Glycoside Hydrolase Inhibitors - pharmacology
Humans
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Lipid Metabolism - drug effects
Methylglyoxal
Mice
Molecular docking
Molecular Docking Simulation
Oligopeptides - chemistry
Oligopeptides - metabolism
Oligopeptides - pharmacology
Pyruvaldehyde - metabolism
α-Glucosidase inhibitory peptides
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Summary:Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; dipeptidyl peptidase-IV inhibition (DPP-IV), lipid accumulation and the differentiation of 3T3-L1 adipocytes, and scavenging of methylglyoxal (MGO), reactive oxygen species (ROS) and nitric oxide (NO). The peptides were subjected to molecular docking on human DPP-IV where the binding free energies were PFP 
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2018.10.152