Whole genome sequence analysis to detect signatures of positive selection for high fecundity in sheep

Contents Ovulation rate and prolificacy are the most important reproductive traits that have major impact on the efficiency of lamb meat production. Here, we compared the whole genomes of the Romanov sheep, known as one of the high prolific breeds, and four other sheep breeds namely Assaf, Awassi, C...

Full description

Saved in:
Bibliographic Details
Published in:Reproduction in domestic animals 2019-02, Vol.54 (2), p.358-364
Main Authors: Nosrati, Maryam, Asadollahpour Nanaei, Hojjat, Amiri Ghanatsaman, Zeinab, Esmailizadeh, Ali
Format: Article
Language:English
Subjects:
Animal husbandry
Animals
Breeding
comparative genomics
Fecundity
Female
Fertility - genetics
Genes
Genome
Genomes
Kruppel-Like Transcription Factors - genetics
Meat
Meat production
Nucleotide sequence
Ovis aries
Ovulation
Ovulation - genetics
Positive selection
Proteins
Receptors, Leptin - genetics
Receptors, Platelet-Derived Growth Factor - genetics
reproductive traits
Romanov sheep
Selection, Genetic
Sheep
Sheep, Domestic - genetics
Signature analysis
Statistical analysis
whole genome sequence
Whole Genome Sequencing - veterinary
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Contents Ovulation rate and prolificacy are the most important reproductive traits that have major impact on the efficiency of lamb meat production. Here, we compared the whole genomes of the Romanov sheep, known as one of the high prolific breeds, and four other sheep breeds namely Assaf, Awassi, Cambridge and British du cher, to identify genetic mechanisms underlying prolificacy in sheep. Selection signature analysis revealed 637 and 477 protein‐coding genes under positive selection from FST and nucleotide diversity (Pi) statistics, respectively. Further analysis showed that several candidate genes including LEPR, PDGFRL and KLF5 genes are involved in sheep prolificacy. The identified candidate genes in the selected regions are novel and provide new insights into the genetic mechanisms underlying prolificacy in sheep and can be useful in sheep breeding programmes to develop improved breeds for high reproductive efficiency.
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.13368