Oxytocin receptor signaling in the hippocampus: Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory

Beyond its well-known role in reproduction, the hypothalamic neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of social and nonsocial behaviors. The biological actions of OXT are exerted through specific OXT receptors (OXTR) that belong to the family of G protein-coupled receptors...

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Bibliographic Details
Published in:Progress in neurobiology 2018-12, Vol.171, p.1-14
Main Authors: Lin, Yu-Ting, Hsu, Kuei-Sen
Format: Article
Language:English
Subjects:
Animals
Hippocampus - cytology
Hippocampus - metabolism
Humans
Memory - physiology
Neuronal Plasticity - physiology
Neurons - physiology
Receptors, Oxytocin - metabolism
Signal Transduction - physiology
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Summary:Beyond its well-known role in reproduction, the hypothalamic neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of social and nonsocial behaviors. The biological actions of OXT are exerted through specific OXT receptors (OXTR) that belong to the family of G protein-coupled receptors. OXTR is abundantly expressed in the hippocampus, and the past decade has witnessed tremendous progress in our understanding of the physiological significance of hippocampal OXTR signaling. In this review, we mainly focus on recent progress made in identifying the role of hippocampal OXTR signaling in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social recognition memory. We also discuss recent insights into the cellular mechanisms underlying these processes regulated by OXTR signaling. Finally, we discuss the remaining questions for future research. A full understanding of the functional role of hippocampal OXTR signaling may lead to targeted new therapies for social cognition deficits, often observed in patients with autism and other neuropsychiatric disorders.
ISSN:0301-0082
1873-5118
DOI:10.1016/j.pneurobio.2018.10.003