Multiple functions of HuR in urinary tumors

Purpose Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ b...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2019-01, Vol.145 (1), p.11-18
Main Authors: Zhang, Fa, Cai, Zhonglin, Lv, Haidi, Li, Wenjuan, Liang, Mengtian, Wei, Xupan, Zhou, Fenghai
Format: Article
Language:English
Subjects:
Cancer
Cancer Research
Chemoresistance
Clinical trials
Embryos
Hematology
HuR protein
Internal Medicine
Medicine
Medicine & Public Health
mRNA turnover
Oncology
Post-transcription
Protein transport
Proteins
Review – Cancer Research
RNA-binding protein
Therapeutic applications
Tumors
Urinary tract
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Summary:Purpose Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ biology and explore the potential role in therapeutic strategies aimed at targeting this molecule in cancer cells. Methods The relevant literature from PubMed and Medline databases is reviewed in this article. Results Increasing evidence supports that HuR plays a critical role in urinary tumors’ biology because it regulates the expression of many urinary tumors-associated molecules through post-transcriptional regulatory mechanisms (including mRNA trafficking, mRNA decay and protein translation). Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment. Conclusion HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What’s more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-018-2778-2