Loading…
Multiple functions of HuR in urinary tumors
Purpose Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ b...
Saved in:
| Published in: | Journal of cancer research and clinical oncology 2019-01, Vol.145 (1), p.11-18 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c372t-8df4abbf9e711f70d9c7bfefa05cc2fd375eb243b6dd4621372a7a6564a9a5e43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c372t-8df4abbf9e711f70d9c7bfefa05cc2fd375eb243b6dd4621372a7a6564a9a5e43 |
| container_end_page | 18 |
| container_issue | 1 |
| container_start_page | 11 |
| container_title | Journal of cancer research and clinical oncology |
| container_volume | 145 |
| creator | Zhang, Fa Cai, Zhonglin Lv, Haidi Li, Wenjuan Liang, Mengtian Wei, Xupan Zhou, Fenghai |
| description | Purpose
Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ biology and explore the potential role in therapeutic strategies aimed at targeting this molecule in cancer cells.
Methods
The relevant literature from PubMed and Medline databases is reviewed in this article.
Results
Increasing evidence supports that HuR plays a critical role in urinary tumors’ biology because it regulates the expression of many urinary tumors-associated molecules through post-transcriptional regulatory mechanisms (including mRNA trafficking, mRNA decay and protein translation). Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment.
Conclusion
HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What’s more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors. |
| doi_str_mv | 10.1007/s00432-018-2778-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2126905039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2126470591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-8df4abbf9e711f70d9c7bfefa05cc2fd375eb243b6dd4621372a7a6564a9a5e43</originalsourceid><addsrcrecordid>eNp1kFtLwzAYhoMobk5_gDdS8EaQ6vfl0KyXMtQJE0H0OqRtIh09zKS58N-b2akgeJOQ5HnfJA8hpwhXCCCvPQBnNAWcp1TKOOyRKW53kDGxT6aAElNBMZuQI-_XENdC0kMyYcAk8DlMyeVjaIZ605jEhq4c6r7zSW-TZXhO6i4Jru60-0iG0PbOH5MDqxtvTnbzjLze3b4slunq6f5hcbNKSybpkM4ry3VR2NxIRCuhyktZWGM1iLKktmJSmIJyVmRVxTOKMaSlzkTGda6F4WxGLsbejevfg_GDamtfmqbRnemDVxRploMAlkf0_A-67oPr4uu-KC5B5BgpHKnS9d47Y9XG1W38mEJQW5NqNKmiSbU1qWjMnO2aQ9Ga6ifxrS4CdAR8POrejPu9-v_WT60HfI4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2126470591</pqid></control><display><type>article</type><title>Multiple functions of HuR in urinary tumors</title><source>Springer Link</source><creator>Zhang, Fa ; Cai, Zhonglin ; Lv, Haidi ; Li, Wenjuan ; Liang, Mengtian ; Wei, Xupan ; Zhou, Fenghai</creator><creatorcontrib>Zhang, Fa ; Cai, Zhonglin ; Lv, Haidi ; Li, Wenjuan ; Liang, Mengtian ; Wei, Xupan ; Zhou, Fenghai</creatorcontrib><description>Purpose
Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ biology and explore the potential role in therapeutic strategies aimed at targeting this molecule in cancer cells.
Methods
The relevant literature from PubMed and Medline databases is reviewed in this article.
Results
Increasing evidence supports that HuR plays a critical role in urinary tumors’ biology because it regulates the expression of many urinary tumors-associated molecules through post-transcriptional regulatory mechanisms (including mRNA trafficking, mRNA decay and protein translation). Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment.
Conclusion
HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What’s more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-018-2778-2</identifier><identifier>PMID: 30370480</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Cancer Research ; Chemoresistance ; Clinical trials ; Embryos ; Hematology ; HuR protein ; Internal Medicine ; Medicine ; Medicine & Public Health ; mRNA turnover ; Oncology ; Post-transcription ; Protein transport ; Proteins ; Review – Cancer Research ; RNA-binding protein ; Therapeutic applications ; Tumors ; Urinary tract</subject><ispartof>Journal of cancer research and clinical oncology, 2019-01, Vol.145 (1), p.11-18</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Journal of Cancer Research and Clinical Oncology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8df4abbf9e711f70d9c7bfefa05cc2fd375eb243b6dd4621372a7a6564a9a5e43</citedby><cites>FETCH-LOGICAL-c372t-8df4abbf9e711f70d9c7bfefa05cc2fd375eb243b6dd4621372a7a6564a9a5e43</cites><orcidid>0000-0003-2976-7961</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30370480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Fa</creatorcontrib><creatorcontrib>Cai, Zhonglin</creatorcontrib><creatorcontrib>Lv, Haidi</creatorcontrib><creatorcontrib>Li, Wenjuan</creatorcontrib><creatorcontrib>Liang, Mengtian</creatorcontrib><creatorcontrib>Wei, Xupan</creatorcontrib><creatorcontrib>Zhou, Fenghai</creatorcontrib><title>Multiple functions of HuR in urinary tumors</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ biology and explore the potential role in therapeutic strategies aimed at targeting this molecule in cancer cells.
Methods
The relevant literature from PubMed and Medline databases is reviewed in this article.
Results
Increasing evidence supports that HuR plays a critical role in urinary tumors’ biology because it regulates the expression of many urinary tumors-associated molecules through post-transcriptional regulatory mechanisms (including mRNA trafficking, mRNA decay and protein translation). Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment.
Conclusion
HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What’s more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors.</description><subject>Cancer</subject><subject>Cancer Research</subject><subject>Chemoresistance</subject><subject>Clinical trials</subject><subject>Embryos</subject><subject>Hematology</subject><subject>HuR protein</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>mRNA turnover</subject><subject>Oncology</subject><subject>Post-transcription</subject><subject>Protein transport</subject><subject>Proteins</subject><subject>Review – Cancer Research</subject><subject>RNA-binding protein</subject><subject>Therapeutic applications</subject><subject>Tumors</subject><subject>Urinary tract</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kFtLwzAYhoMobk5_gDdS8EaQ6vfl0KyXMtQJE0H0OqRtIh09zKS58N-b2akgeJOQ5HnfJA8hpwhXCCCvPQBnNAWcp1TKOOyRKW53kDGxT6aAElNBMZuQI-_XENdC0kMyYcAk8DlMyeVjaIZ605jEhq4c6r7zSW-TZXhO6i4Jru60-0iG0PbOH5MDqxtvTnbzjLze3b4slunq6f5hcbNKSybpkM4ry3VR2NxIRCuhyktZWGM1iLKktmJSmIJyVmRVxTOKMaSlzkTGda6F4WxGLsbejevfg_GDamtfmqbRnemDVxRploMAlkf0_A-67oPr4uu-KC5B5BgpHKnS9d47Y9XG1W38mEJQW5NqNKmiSbU1qWjMnO2aQ9Ga6ifxrS4CdAR8POrejPu9-v_WT60HfI4</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Zhang, Fa</creator><creator>Cai, Zhonglin</creator><creator>Lv, Haidi</creator><creator>Li, Wenjuan</creator><creator>Liang, Mengtian</creator><creator>Wei, Xupan</creator><creator>Zhou, Fenghai</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2976-7961</orcidid></search><sort><creationdate>20190101</creationdate><title>Multiple functions of HuR in urinary tumors</title><author>Zhang, Fa ; Cai, Zhonglin ; Lv, Haidi ; Li, Wenjuan ; Liang, Mengtian ; Wei, Xupan ; Zhou, Fenghai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8df4abbf9e711f70d9c7bfefa05cc2fd375eb243b6dd4621372a7a6564a9a5e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cancer</topic><topic>Cancer Research</topic><topic>Chemoresistance</topic><topic>Clinical trials</topic><topic>Embryos</topic><topic>Hematology</topic><topic>HuR protein</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>mRNA turnover</topic><topic>Oncology</topic><topic>Post-transcription</topic><topic>Protein transport</topic><topic>Proteins</topic><topic>Review – Cancer Research</topic><topic>RNA-binding protein</topic><topic>Therapeutic applications</topic><topic>Tumors</topic><topic>Urinary tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Fa</creatorcontrib><creatorcontrib>Cai, Zhonglin</creatorcontrib><creatorcontrib>Lv, Haidi</creatorcontrib><creatorcontrib>Li, Wenjuan</creatorcontrib><creatorcontrib>Liang, Mengtian</creatorcontrib><creatorcontrib>Wei, Xupan</creatorcontrib><creatorcontrib>Zhou, Fenghai</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Fa</au><au>Cai, Zhonglin</au><au>Lv, Haidi</au><au>Li, Wenjuan</au><au>Liang, Mengtian</au><au>Wei, Xupan</au><au>Zhou, Fenghai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple functions of HuR in urinary tumors</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>145</volume><issue>1</issue><spage>11</spage><epage>18</epage><pages>11-18</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ biology and explore the potential role in therapeutic strategies aimed at targeting this molecule in cancer cells.
Methods
The relevant literature from PubMed and Medline databases is reviewed in this article.
Results
Increasing evidence supports that HuR plays a critical role in urinary tumors’ biology because it regulates the expression of many urinary tumors-associated molecules through post-transcriptional regulatory mechanisms (including mRNA trafficking, mRNA decay and protein translation). Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment.
Conclusion
HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What’s more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30370480</pmid><doi>10.1007/s00432-018-2778-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2976-7961</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2019-01, Vol.145 (1), p.11-18 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2126905039 |
| source | Springer Link |
| subjects | Cancer Cancer Research Chemoresistance Clinical trials Embryos Hematology HuR protein Internal Medicine Medicine Medicine & Public Health mRNA turnover Oncology Post-transcription Protein transport Proteins Review – Cancer Research RNA-binding protein Therapeutic applications Tumors Urinary tract |
| title | Multiple functions of HuR in urinary tumors |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A43%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multiple%20functions%20of%20HuR%20in%20urinary%20tumors&rft.jtitle=Journal%20of%20cancer%20research%20and%20clinical%20oncology&rft.au=Zhang,%20Fa&rft.date=2019-01-01&rft.volume=145&rft.issue=1&rft.spage=11&rft.epage=18&rft.pages=11-18&rft.issn=0171-5216&rft.eissn=1432-1335&rft_id=info:doi/10.1007/s00432-018-2778-2&rft_dat=%3Cproquest_cross%3E2126470591%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c372t-8df4abbf9e711f70d9c7bfefa05cc2fd375eb243b6dd4621372a7a6564a9a5e43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2126470591&rft_id=info:pmid/30370480&rfr_iscdi=true |