Intratumoral infiltrating lymphocytes correlate with improved survival in colorectal cancer patients: Independent of oncogenetic features

Background The clinical relevance and prognostic value of tumor‐infiltrating lymphocytes (TILs) as an interplay between malignant cells and immune function has been known for decades. On contrary, this potential may be different by T lymphocytes subsets endowed with a different function. Colorectal...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular physiology 2019-04, Vol.234 (4), p.4768-4777
Main Authors: Nazemalhosseini‐Mojarad, Ehsan, Mohammadpour, Somayeh, Torshizi Esafahani, Amir, Gharib, Ehsan, Larki, Pegah, Moradi, Afshin, Amin Porhoseingholi, Mohammad, Asadzade Aghdaei, Hamid, Kuppen, Peter J. K., Zali, Mohammad Reza
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anticancer properties
Antitumor activity
Biomarkers
Cancer
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Cell Differentiation
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - immunology
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Diagnostic systems
Differentiation
Female
Genetics
Humans
Immune response
Infiltration
Lymphatic Metastasis
Lymphocytes
Lymphocytes T
Lymphocytes, Tumor-Infiltrating - immunology
Male
Medical prognosis
Metastases
Microsatellite Instability
Middle Aged
Mutation
Neoplasm Staging
Paraffin
Paraffins
Patients
prognostic biomarker
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins p21(ras) - genetics
Stability
Statistical analysis
Statistical methods
Survival
Time Factors
Tumors
tumor‐infiltrating lymphocytes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The clinical relevance and prognostic value of tumor‐infiltrating lymphocytes (TILs) as an interplay between malignant cells and immune function has been known for decades. On contrary, this potential may be different by T lymphocytes subsets endowed with a different function. Colorectal cancer (CRC) is a heterogeneous disease with different suggested prognostic biomarkers. So, this study was conducted to examine the prognostic value of CD8+ TILs on the survival rate of CRC as an independent factor of oncogenetic tumor features. Methods With respect to this, 281 formalin‐fixed, paraffin‐embedded tissue samples of Iranian CRC patients were evaluated for clinical features including tumor location, tumor stage, differentiation grade, and mucinous characteristics. Then, using the standard immunohistochemical technique, tumor sections were examined, and CD8+ TILs were counted and identified in two regions of the tumor, including intratumoral (ITCIL TILs) and stromal (S TILs). The prognostic value of CD8+ TILs was determined by comparing with parameters, such as diagnostic age, tumor stage, adjuvant therapy, microsatellite instability (MSI) status, KRAS and BRAF mutations, family history, and survival. Results The presence of intratumoral tumor cell‐infiltrating lymphocytes (ITCIL) CD8+ lymphocytes are significantly associated with differentiation (p = 0.004), tumor, node, and metastases (TNM) stage (p = 0.001), and MSI (p = 0.001). Meanwhile, based on the level of stromal infiltrating lymphocytes (SIL) infiltration, analysis of CRC patients was statistically associated with a location (p = 0.002), TNM stage (p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.27273