VISA–Daptomycin non-susceptible Staphylococcus aureus frequently demonstrate non-susceptibility to Telavancin

Telavancin was evaluated against S. aureus isolates with reduced susceptibility to other antimicrobial agents using two broth microdilution methods and Etest® strips. The three methods provided comparable results. Differences in telavancin susceptibility versus non-susceptibility were noted mainly i...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2019-02, Vol.93 (2), p.159-161
Main Authors: Saravolatz, Louis D., Pawlak, Joan
Format: Article
Language:English
Subjects:
CLSI
Daptomycin
Methicillin-resistant Staphylococcus aureus
Staphylococcus aureus
Telavancin
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Summary:Telavancin was evaluated against S. aureus isolates with reduced susceptibility to other antimicrobial agents using two broth microdilution methods and Etest® strips. The three methods provided comparable results. Differences in telavancin susceptibility versus non-susceptibility were noted mainly in the VISA-daptomycin non-susceptible group of isolates. In this group the percent susceptibility was 38% for the Etest® method and 50% and 54% for the 2 broth microdilution methods. All differences in susceptibility were within one 2-fold dilution. •Many VISA, daptomycin non-susceptible S. aureus are not susceptible to telavancin.•There is agreement in MIC's using broth micro dilution methods and Etest strips.•VRSA isolates are telavancin resistant
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2018.09.003