The paraventricular thalamus is a critical thalamic area for wakefulness

Clinical observations indicate that the paramedian region of the thalamus is a critical node for controlling wakefulness. However, the specific nucleus and neural circuitry for this function remain unknown. Using in vivo fiber photometry or multichannel electrophysiological recordings in mice, we fo...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2018-10, Vol.362 (6413), p.429-434
Main Authors: Ren, Shuancheng, Wang, Yaling, Yue, Faguo, Cheng, Xiaofang, Dang, Ruozhi, Qiao, Qicheng, Sun, Xueqi, Li, Xin, Jiang, Qian, Yao, Jiwei, Qin, Han, Wang, Guanzhong, Liao, Xiang, Gao, Dong, Xia, Jianxia, Zhang, Jun, Hu, Bo, Yan, Junan, Wang, Yanjiang, Xu, Min, Han, Yunyun, Tang, Xiangdong, Chen, Xiaowei, He, Chao, Hu, Zhian
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Brain stem
Cerebral cortex
Circuits
Electrophysiology - methods
Female
Forebrain
Glutamatergic transmission
Glutamic Acid
Hypothalamus
Hypothalamus (lateral)
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Midline Thalamic Nuclei - physiology
Neural networks
Neurons
Neurons - physiology
Nucleus accumbens
Nucleus Accumbens - physiology
Optogenetics
Orexins
Orexins - genetics
Photometry
Photometry - methods
Proto-Oncogene Proteins c-fos - metabolism
Reinforcement
Rodents
Sensory stimuli
Sleep
Sleep and wakefulness
Somatosensory cortex
Thalamus
Wakefulness
Wakefulness - physiology
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Summary:Clinical observations indicate that the paramedian region of the thalamus is a critical node for controlling wakefulness. However, the specific nucleus and neural circuitry for this function remain unknown. Using in vivo fiber photometry or multichannel electrophysiological recordings in mice, we found that glutamatergic neurons of the paraventricular thalamus (PVT) exhibited high activities during wakefulness. Suppression of PVT neuronal activity caused a reduction in wakefulness, whereas activation of PVT neurons induced a transition from sleep to wakefulness and an acceleration of emergence from general anesthesia. Moreover, our findings indicate that the PVT-nucleus accumbens projections and hypocretin neurons in the lateral hypothalamus to PVT glutamatergic neurons' projections are the effector pathways for wakefulness control. These results demonstrate that the PVT is a key wakefulness-controlling nucleus in the thalamus.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aat2512